journal article·2024-04Open access

Upconversion 3D Bioprinting for Noninvasive In Vivo Molding

Peng Zhang, Zhaowei Teng, Min Zhou, Xue Yu, Hongyu Wen, Junzheng Niu, Zhichao Liu, Zhimeng Zhang, Yang Liu, Jianbei Qiu, Xuhui Xu

Advanced Materials· Volume 36· Issue 14

Abstract

Abstract Tissue engineered bracket materials provide essential support for the physiological protection and therapeutics of patients. Unfortunately, the implantation process of such devices poses the risk of surgical complications and infection. In this study, an upconversion nanoparticles (UCNPs)‐assisted 3D bioprinting approach is developed to realize in vivo molding that is free from invasive surgery. Reasonably designed UCNPs, which convert near‐infrared (NIR) photons that penetrate skin tissues into blue–violet emission (300–500 nm), induce a monomer polymerization curing procedure in vivo. Using a fused deposition modeling coordination framework, a precisely predetermined trajectory of the NIR laser enables the manufacture of implantable medical devices with tailored shapes. A proof of the 3D bioprinting of a noninvasive fracture fixation scaffold is achieved successfully, thus demonstrating an entirely new method of in vivo molding for biomedical treatment.
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Research context

OpenAlex topics: 3D Printing in Biomedical Research · Additive Manufacturing and 3D Printing Technologies · Bone Tissue Engineering Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Faculty of Materials Science and Engineering Yunnan Joint International Laboratory of Optoelectronic Materials and Devices Kunming University of Science and Technology Kunming Yunnan 650093 P. R. China

The Central Laboratory and Department of orthopedic The Second Affiliated Hospital of Kunming Medical University Kunming 650106 P. R. China

Department of orthopedic The First Peoples Hospital of Yunnan Province Affiliated Hospital of Kunming University of Science and Technology Kunming 650034 P. R. China

College of Physical Science and Technology Yangzhou University Yangzhou Jiangsu 225002 P. R. China

School of Mechanical Engineering Institute for Advanced Study Chengdu University Chengdu Sichuan 610106 P. R. China

Center for Life Sciences School of Life Sciences State Key Laboratory for Conservation and Utilization of Bio‐Resources in Yunnan Yunnan University Kunming Yunnan 650500 P. R. China

College of Electrical Energy and Power Engineering Yangzhou University Yangzhou Jiangsu 225002 P. R. China

Funding

National Natural Science Foundation of China · Special Fund for Scientific Innovation Strategy-Construction of High-level Academy of Agriculture Science · Cultivating Plan Program for the Leader in Science and Technology of Yunnan Province

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