journal article·2023-05Open access

Gadolinium (III)‐Chelated Deformable Mesoporous Organosilica Nanoparticles as Magnetic Resonance Imaging Contrast Agent

Xiangyu Chen, Shiyong Teng, Jinming Li, Xuezhi Qiao, Weidong Zhao, Zhengjie Xue, Xudong Shi, Yuguang Wang, Wensheng Yang, Tie Wang

Advanced Materials· Volume 35· Issue 20

Abstract

Abstract Magnetic resonance imaging (MRI) contrast agents, such as Magnevist (Gd‐DTPA), are routinely used for detecting tumors at an early stage. However, the rapid clearance by the kidney of Gd‐DTPA leads to short blood circulation time, which limits further improvement of the contrast between tumorous and normal tissue. Inspired by the deformability of red blood cells, which improves their blood circulation, this work fabricates a novel MRI contrast agent by incorporating Gd‐DTPA into deformable mesoporous organosilica nanoparticles (D‐MON). In vivo distribution shows that the novel contrast agent is able to depress rapid clearance by the liver and spleen, and the mean residence time is 20 h longer than Gd‐DTPA. Tumor MRI studies demonstrated that the D‐MON‐based contrast agent is highly enriched in the tumor tissue and achieves prolonged high‐contrast imaging. D‐MON significantly improves the performance of clinical contrast agent Gd‐DTPA, exhibiting good potential in clinical applications.
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Research context

OpenAlex topics: Advanced MRI Techniques and Applications · Lanthanide and Transition Metal Complexes · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Life and Health Intelligent Research Institute Tianjin University of Technology Tianjin 300384 P. R. China

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun 130022 P. R. China

Beijing National Laboratory for Molecular Sciences Key Laboratory of Analytical Chemistry for Living Biosystems Institute of Chemistry Chinese Academy of Sciences CAS Beijing 100049 P. R. China

NHC Key Laboratory of Human Disease Comparative Medicine Institute of Laboratory Animal Sciences Peking Union Medicine College Chinese Academy of Medical Sciences Beijing 100021 P. R. China

Center of Digital Dentistry Peking University School and Hospital of Stomatology NHC Research Center of Engineering and Technology for Computerized Dentistry Beijing 100081 P. R. China

Funding

National Natural Science Foundation of China · National Key Research and Development Program of China · Chinese Academy of Sciences · China Postdoctoral Science Foundation

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