Dual Behavior Regulation: Tether‐Free Deep‐Brain Stimulation by Photothermal and Upconversion Hybrid Nanoparticles

Feiyi Sun; Hanchen Shen; Qinghu Yang; Zhaoyue Yuan; Yuyang Chen; Weihua Guo; Yu Wang; Liang Yang; Zhantao Bai; Qingqing Liu; Ming Jiang; Jacky W. Y. Lam; Jianwei Sun; Ruquan Ye; Ryan T. K. Kwok; Ben Zhong Tang

doi:10.1002/adma.202210018

journal article·2023-05

Dual Behavior Regulation: Tether‐Free Deep‐Brain Stimulation by Photothermal and Upconversion Hybrid Nanoparticles

Feiyi Sun, Hanchen Shen, Qinghu Yang, Zhaoyue Yuan, Yuyang Chen, Weihua Guo, Yu Wang, Liang Yang, Zhantao Bai, Qingqing Liu, Ming Jiang, Jacky W. Y. Lam, Jianwei Sun, Ruquan Ye, Ryan T. K. Kwok, Ben Zhong Tang

Advanced Materials· Volume 35· Issue 21

Publisher page

Source abstract

Abstract

Abstract Optogenetics has been plagued by invasive brain implants and thermal effects during photo‐modulation. Here, two upconversion hybrid nanoparticles modified with photothermal agents, named PT‐UCNP‐B/G, which can modulate neuronal activities via photostimulation and thermo‐stimulation under near‐infrared laser irradiation at 980 nm and 808 nm, respectively, are demonstrated. PT‐UCNP‐B/G emits visible light (410–500 nm or 500–570 nm) through the upconversion process at 980 nm, while they exhibit efficient photothermal effect at 808 nm with no visible emission and tissue damage. Intriguingly, PT‐UCNP‐B significantly activates extracellular sodium currents in neuro2a cells expressing light‐gated channelrhodopsin‐2 (ChR2) ion channels under 980‐nm irradiation, and inhibits potassium currents in human embryonic kidney 293 cells expressing the voltage‐gated potassium channels (KCNQ1) under 808‐nm irradiation in vitro. Furthermore, deep‐brain bidirectional modulation of feeding behavior is achieved under tether‐free 980 or 808‐nm illumination (0.8 W cm⁻²) in mice stereotactically injected with PT‐UCNP‐B in the ChR2‐expressing lateral hypothalamus region. Thus, PT‐UCNP‐B/G creates new possibility of utilizing both light and heat to modulate neural activities and provides a viable strategy to overcome the limits of optogenetics.

Source: crossref · Quality: baseline

Research context

Nanomaterials Biomaterials

OpenAlex topics: Photoreceptor and optogenetics research · Nicotinic Acetylcholine Receptors Study · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction and State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science & Technology Kowloon Hong Kong 999077 P. R. China

College of Life Science & Research Center for Natural Peptide Drugs Shaanxi Engineering & Technological Research Center for Conversation & Utilization of Regional Biological Resources Yanan University Yanan 716000 P. R. China

Department of Chemistry State Key Laboratory of Marine Pollution City University of Hong Kong Hong Kong 999077 P. R. China

School of Chinese Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Pokfulam Hong Kong 999077 P. R. China

School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong Shenzhen 518172 P. R. China

Center of Aggregation‐Induced Emission South China University of Technology Guangzhou 510640 P. R. China

Funding

National Natural Science Foundation of China · Innovation and Technology Commission

References (80)

Show source-provided references

1. 10.1002/hipo.2296010.1002/hipo.22960 ↗

2. 10.1002/cbic.20180001310.1002/cbic.201800013 ↗

3. 10.1038/nn152510.1038/nn1525 ↗

4. 10.1126/science.124181210.1126/science.1241812 ↗

5. 10.1016/j.celrep.2021.10961510.1016/j.celrep.2021.109615 ↗

6. 10.1038/nbt.314010.1038/nbt.3140 ↗

7. 10.1002/adma.20180347410.1002/adma.201803474 ↗

8. 10.1021/cn300065j10.1021/cn300065j ↗

9. Mobley J. · 2014 · 23

10. 10.1088/0031-9155/58/11/R3710.1088/0031-9155/58/11/R37 ↗

11. 10.1038/s41551-017-0154-110.1038/s41551-017-0154-1 ↗

12. 10.1017/978110728187510.1017/9781107281875 ↗

13. 10.1002/adma.20200880910.1002/adma.202008809 ↗

14. 10.3389/fnbeh.2013.0016910.3389/fnbeh.2013.00169 ↗

15. 10.1016/j.celrep.2018.06.11910.1016/j.celrep.2018.06.119 ↗

16. 10.1364/OL.38.00099210.1364/OL.38.000992 ↗

17. 10.1038/s41593-021-00849-x10.1038/s41593-021-00849-x ↗

18. 10.1038/nmeth81810.1038/nmeth818 ↗

19. 10.1038/s41587-021-01036-w10.1038/s41587-021-01036-w ↗

20. 10.1016/j.neuron.2021.03.01310.1016/j.neuron.2021.03.013 ↗

21. 10.1038/s41467-021-25993-710.1038/s41467-021-25993-7 ↗

22. 10.1126/science.aaq114410.1126/science.aaq1144 ↗

23. 10.1002/adhm.20220030410.1002/adhm.202200304 ↗

24. 10.1073/pnas.180206411510.1073/pnas.1802064115 ↗

25. 10.1021/cr020357g10.1021/cr020357g ↗

26. 10.1021/acscentsci.0c0054410.1021/acscentsci.0c00544 ↗

27. 10.1002/adfm.20060005310.1002/adfm.200600053 ↗

28. 10.1039/C6DT01187J10.1039/C6DT01187J ↗

29. 10.1016/j.nano.2011.02.01310.1016/j.nano.2011.02.013 ↗

30. 10.1073/pnas.101517810810.1073/pnas.1015178108 ↗

31. 10.1038/sj.emboj.760108310.1038/sj.emboj.7601083 ↗

32. 10.1038/ncomms174210.1038/ncomms1742 ↗

33. 10.1038/s41378-020-0153-310.1038/s41378-020-0153-3 ↗

34. 10.1021/acsnano.0c0370310.1021/acsnano.0c03703 ↗

35. 10.1126/science.126182110.1126/science.1261821 ↗

36. 10.1021/acsmaterialslett.9b0029210.1021/acsmaterialslett.9b00292 ↗

37. 10.1038/s41467-019-08739-410.1038/s41467-019-08739-4 ↗

38. 10.1002/anie.20220460410.1002/anie.202204604 ↗

39. 10.1039/D0SC03160G10.1039/D0SC03160G ↗

40. 10.1016/j.ccr.2017.10.00610.1016/j.ccr.2017.10.006 ↗

41. 10.1016/j.biomaterials.2013.04.06610.1016/j.biomaterials.2013.04.066 ↗

42. 10.1021/jacs.8b1388910.1021/jacs.8b13889 ↗

43. 10.3389/fbioe.2019.0048710.3389/fbioe.2019.00487 ↗

44. 10.1016/j.ccr.2020.21323310.1016/j.ccr.2020.213233 ↗

45. 10.1039/C7QI00046D10.1039/C7QI00046D ↗

46. 10.1007/s11426-021-1189-910.1007/s11426-021-1189-9 ↗

47. 10.1021/acs.accounts.5b0007810.1021/acs.accounts.5b00078 ↗

48. 10.1002/agt2.5910.1002/agt2.59 ↗

49. 10.1126/sciadv.abb271210.1126/sciadv.abb2712 ↗

50. 10.1021/acs.langmuir.5b0096310.1021/acs.langmuir.5b00963 ↗

51. 10.1529/biophysj.107.10478610.1529/biophysj.107.104786 ↗

52. 10.1146/annurev.neuro.29.051605.11295810.1146/annurev.neuro.29.051605.112958 ↗

53. 10.1073/pnas.193619210010.1073/pnas.1936192100 ↗

54. 10.1111/j.1476-5381.2009.00111.x10.1111/j.1476-5381.2009.00111.x ↗

55. 10.1038/s41592-019-0581-x10.1038/s41592-019-0581-x ↗

56. 10.7554/eLife.1272710.7554/eLife.12727 ↗

57. 10.1523/JNEUROSCI.1202-15.201610.1523/JNEUROSCI.1202-15.2016 ↗

58. 10.1109/TBME.2020.300124210.1109/TBME.2020.3001242 ↗

59. 10.1038/s41467-022-28539-710.1038/s41467-022-28539-7 ↗

60. 10.1038/s41593-017-0018-810.1038/s41593-017-0018-8 ↗

61. 10.1038/s41586-018-0866-810.1038/s41586-018-0866-8 ↗

62. 10.1038/nn.409110.1038/nn.4091 ↗

63. 10.4161/cib.770810.4161/cib.7708 ↗

64. 10.1089/pho.2012.328410.1089/pho.2012.3284 ↗

65. 10.1016/j.biopsych.2011.12.02610.1016/j.biopsych.2011.12.026 ↗

66. 10.1016/j.brainres.2013.01.02610.1016/j.brainres.2013.01.026 ↗

67. 10.1001/archneurol.2010.26010.1001/archneurol.2010.260 ↗

68. 10.1016/j.conb.2003.11.00110.1016/j.conb.2003.11.001 ↗

69. 10.1038/s41551-022-00862-w10.1038/s41551-022-00862-w ↗

70. 10.1038/s41551-016-001010.1038/s41551-016-0010 ↗

71. 10.1186/s13041-019-0530-810.1186/s13041-019-0530-8 ↗

72. 10.1364/OME.6.00116110.1364/OME.6.001161 ↗

73. 10.1021/jp110603r10.1021/jp110603r ↗

74. 10.1021/j100096a00110.1021/j100096a001 ↗

75. 10.1080/0026897740010017110.1080/00268977400100171 ↗

76. 10.1063/1.338234410.1063/1.3382344 ↗

77. 10.1039/C4DT00424H10.1039/C4DT00424H ↗

78. 10.1002/adma.20190785510.1002/adma.201907855 ↗

79. 10.1038/s41467-020-16698-410.1038/s41467-020-16698-4 ↗

80. 10.1016/j.pneurobio.2021.10220910.1016/j.pneurobio.2021.102209 ↗