journal article·2023-07Open access

Inhibition of Tumor Metastasis by Liquid‐Nitrogen‐Shocked Tumor Cells with Oncolytic Viruses Infection

Qing Wu, Hanwei Huang, Mengchi Sun, Ruizhe Zhang, Junxia Wang, Hanqi Zheng, Chaojie Zhu, Shihua Yang, Xinyuan Shen, Jiaqi Shi, Feng Liu, Wei Wu, Jin Sun, Funan Liu, Hongjun Li, Zhen Gu

Advanced Materials· Volume 35· Issue 28

Abstract

Abstract Despite the superior tumor lytic efficacy of oncolytic viruses (OVs), their systemic delivery still faces the challenges of limited circulating periods, poor tumor tropism, and spontaneous antiviral immune responses. Herein, a virus‐concealed tumor‐targeting strategy enabling OVs‘ delivery toward lung metastasis via systemic administration is described. The OVs can actively infect, be internalized, and cloak into tumor cells. Then the tumor cells are subsequently treated with liquid‐nitrogen‐shocking to eliminate the pathogenicity. Such a Trojan Horse‐like vehicle avoids virus neutralization and clearance in the bloodstream and facilitates tumor‐targeted delivery for more than 110‐fold virus enrichment in the tumor metastasis. In addition, this strategy can serve as a tumor vaccine and initiate endogenous adaptive antitumor effects through increasing the memory T cells and modulating the tumor immune microenvironment, including reducing the M2 macrophage, downregulating Treg cells, and priming T cells.
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Research context

OpenAlex topics: Virus-based gene therapy research · CAR-T cell therapy research · RNA Interference and Gene Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical Sciences Zhejiang University 310058 Hangzhou P. R. China

Liangzhu Laboratory Zhejiang University Medical Center Hangzhou 311121 P. R. China

Department of Surgical Oncology and General Surgery The First Hospital of China Medical University Key Laboratory of Precision Diagnosis and Treatment of Gastrointestinal Tumors China Medical University Ministry of Education Shenyang 110001 P. R. China

Phase I Clinical Trails Center The First Hospital of China Medical University Shenyang 110102 P. R. China

Wuya College of Innovation Shenyang Pharmaceutical University 110016 Shenyang P. R. China

Department of Hepatobiliary and Pancreatic Surgery the Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 P. R. China

Jinhua Institute of Zhejiang University Jinhua 321299 P. R. China

Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 P. R. China

MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 P. R. China

Funding

National Natural Science Foundation of China

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