DataVXAdvanced MaterialsPaper
journal article·2024-12Open access

Programmable Artificial Skins Accomplish Antiscar Healing with Multiple Appendage Regeneration

Mingchen Xiong, Xinling Yang, Ziwei Shi, Jiangbing Xiang, Huanhuan Gao, Shuaifei Ji, Yingying Li, Wei Pi, Huating Chen, Hongliang Zhang, Mengyang Wang, Yan Li, Yiyue Hong, Dongsheng Liu, Xiaobing Fu, Yuanchen Dong, Xiaoyan Sun

Advanced Materials· Volume 36· Issue 50
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Source abstract

Abstract

Abstract Functional appendage regeneration is essential for skin rehabilitation, but it has always failed by current existing healing approaches, owing to their inefficacy in preventing disfiguring scars. In this study, a novel regeneration‐directing artificial skin (RDAS) system is presented, which is based on the rational design of multi‐layered hydrogels that closely mimic natural skin matrices. By leveraging the programmability and architectural rigidity of DNA components, without the need for exogenous cell transplantation, such RDAS effectively minimizes tissue fibrosis by accurately guiding the regenerative process in wound fibroblasts, enabling rapid scarless wound repair, restoration of dermal function, and successful in situ regeneration of multiple appendages, such as hair follicles (HFs), sebaceous glands (SGs), and sweat glands (SwGs). Therefore, the RDAS offers a cell‐free antiscarring therapeutic strategy for regenerative wound healing, resulting in improved outcomes. This innovative approach holds great potential for future clinical applications and burn rehabilitation.
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Research context

Polymers

OpenAlex topics: Wound Healing and Treatments · Silk-based biomaterials and applications · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Research Center for Tissue Repair and Regeneration affiliated to the Medical Innovation Research Department PLA General Hospital and PLA Medical College Beijing 100048 P. R. China

State Key Laboratory of Trauma and Chemical Poisoning Beijing 100048 P. R. China

PLA Key Laboratory of Tissue Repair and Regenerative Medicine and Beijing Key Research Laboratory of Skin Injury Repair and Regeneration Beijing 100048 P. R. China

Research Unit of Trauma Care, Tissue Repair and Regeneration Chinese Academy of Medical Sciences 2019RU051 Beijing 100048 P. R. China

CAS Key Laboratory of Colloid Interface and Chemical Thermodynamics Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China

University of Chinese Academy of Sciences Beijing 100049 P. R. China

State Key Laboratory of Pharmaceutical Biotechnology School of Life Sciences Nanjing University Nanjing Jiangsu 210023 P. R. China

Key Laboratory of Organic Optoelectronics & Molecular Engineering of the Ministry of Education Department of Chemistry Tsinghua University Beijing 100084 P. R. China

Funding

National Natural Science Foundation of China · National Key Research and Development Program of China

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