Bioresponsive Immunotherapeutic Materials
Source abstract
Abstract
Abstract The human immune system is an interaction network of biological processes, and its dysfunction is closely associated with a wide array of diseases, such as cancer, infectious diseases, tissue damage, and autoimmune diseases. Manipulation of the immune response network in a desired and controlled fashion has been regarded as a promising strategy for maximizing immunotherapeutic efficacy and minimizing side effects. Integration of “smart” bioresponsive materials with immunoactive agents including small molecules, biomacromolecules, and cells can achieve on‐demand release of agents at targeted sites to reduce overdose‐related toxicity and alleviate off‐target effects. This review highlights the design principles of bioresponsive immunotherapeutic materials and discusses the critical roles of controlled release of immunoactive agents from bioresponsive materials in recruiting, housing, and manipulating immune cells for evoking desired immune responses. Challenges and future directions from the perspective of clinical translation are also discussed.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · RNA Interference and Gene Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Zhejiang Provincial Key Laboratory for Advanced Drug Delivery Systems College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China
Department of Burns and Wound Center Second Affiliated Hospital School of Medicine Zhejiang University Hangzhou 310009 China
Department of Materials Science and Engineering Drexel University Philadelphia PA 19104 USA
Cancer Center Zhejiang University Hangzhou 310058 China
Jinhua Institute of Zhejiang University Jinhua 321299 China
Liangzhu Laboratory Zhejiang University Medical Center Hangzhou 311121 China
Department of General Surgery Sir Run Run Hospital School of Medicine Zhejiang University Hangzhou 310016 China
MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China
Funding
National Natural Science Foundation of China · Juvenile Diabetes Research Foundation International
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