journal article·2024-06

Minimally Invasive Delivery of Percutaneous Ablation Agent via Magnetic Colloidal Hydrogel Injection for Treatment of Hepatocellular Carcinoma

Wen‐Shu Wu, Xu Yan, Sheng Chen, Yaxin Du, Jinlong Hu, Yonghong Song, Zhengbao Zha, Yun‐Jun Xu, Baoqiang Cao, Shou‐Hu Xuan, Xingyu Liu, Bing Chen, Liang Dong, Yang Lu, Shu‐Hong Yu

Advanced Materials· Volume 36· Issue 26
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Abstract

Abstract Percutaneous thermotherapy, a minimally invasive operational procedure, is employed in the ablation of deep tumor lesions by means of target‐delivering heat. Conventional thermal ablation methods, such as radiofrequency or microwave ablation, to a certain extent, are subjected to extended ablation time as well as biosafety risks of unwanted overheating. Given its effectiveness and safety, percutaneous thermotherapy gains a fresh perspective, thanks to magnetic hyperthermia. In this respect, an injectable‐ and magnetic‐hydrogel‐construct‐based thermal ablation agent is likely to be a candidate for the aforementioned clinical translation. Adopting a simple and environment‐friendly strategy, a magnetic colloidal hydrogel injection is introduced by a binary system comprising super‐paramagnetic Fe3O4 nanoparticles and gelatin nanoparticles. The colloidal hydrogel constructs, unlike conventional bulk hydrogel, can be easily extruded through a percutaneous needle and then self‐heal in a reversible manner owing to the unique electrostatic cross‐linking. The introduction of magnetic building blocks is exhibited with a rapid magnetothermal response to an alternating magnetic field. Such hydrogel injection is capable of generating heat without limitation of deep penetration. The materials achieve outstanding therapeutic results in mouse and rabbit models. These findings constitute a new class of locoregional interventional thermal therapies with minimal collateral damages.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Hepatocellular Carcinoma Treatment and Prognosis · Endoplasmic Reticulum Stress and Disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Advanced Catalytic Materials and Reaction Engineering School of Chemistry and Chemical Engineering School of Food and Biological Engineering Hefei University of Technology Hefei 230009 China

Department of General Surgery Department of Ultrasonics Department of Interventional Radiology Anhui No. 2 Provincial People's Hospital Hefei Anhui 230041 P. R. China

New Cornerstone Science Laboratory, Division of Nanomaterials and Chemistry Hefei National Research Center for Physical Sciences at the Microscale Department of Radiology The First Affiliated Hospital of University of Science and Technology of China University of Science and Technology of China Hefei 230026 China

CAS Key Laboratory of Mechanical Behavior and Design of Materials Department of Modern Mechanics CAS Center for Excellence in Complex System Mechanics University of Science and Technology of China Hefei 230027 China

Zhejiang Cancer Hospital Hangzhou Institute of Medicine (HIM) Chinese Academy of Sciences Hangzhou Zhejiang 310022 China

Funding

National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities · Natural Science Foundation of Anhui Province · China Postdoctoral Science Foundation · National Key Research and Development Program of China

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