Engineering DNA‐Guided Hydroxyapatite Bulk Materials with High Stiffness and Outstanding Antimicrobial Ability for Dental Inlay Applications

Yusai Zhou; Jingjing Deng; Yi Zhang; Cong Li; Zheng Wei; Jianlei Shen; Jingjing Li; Fan Wang; Bing Han; Dong Chen; Chunhai Fan; Hongjie Zhang; Kai Liu; Yan Wei

doi:10.1002/adma.202202180

journal article·2022-07

Engineering DNA‐Guided Hydroxyapatite Bulk Materials with High Stiffness and Outstanding Antimicrobial Ability for Dental Inlay Applications

Yusai Zhou, Jingjing Deng, Yi Zhang, Cong Li, Zheng Wei, Jianlei Shen, Jingjing Li, Fan Wang, Bing Han, Dong Chen, Chunhai Fan, Hongjie Zhang, Kai Liu, Yan Wei

Advanced Materials· Volume 34· Issue 27

Publisher page

Source abstract

Abstract

Abstract Programmable base pair interactions at the nanoscale make DNA an attractive scaffold for forming hydroxyapatite (HAP) nanostructures. However, engineering macroscale HAP mineralization guided by DNA molecules remains challenging. To overcome this issue, a facile strategy is developed for the fabrication of ultrastiff DNA–HAP bulk composites. The electrostatic complexation of DNA and a surfactant with a quaternary ammonium salt group enables the formation of long‐range ordered scaffolds using electrospinning. The growth of 1D and 2D HAP minerals is thus realized by this DNA template at a macroscale. Remarkably, the as‐prepared DNA–HAP composites exhibit an ultrahigh Young's modulus of ≈25 GPa, which is comparable to natural HAP and superior to most artificial mineralized composites. Furthermore, a new type of dental inlay with outstanding antibacterial properties is developed using the stiff DNA–HAP. The encapsulated quaternary ammonium group within the dense HAP endows the composite with long‐lasting and local antibacterial activity. Therefore, this new type of super‐stiff biomaterial holds great potential for oral prosthetic applications.

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Research context

Nanomaterials Biomaterials Composites

OpenAlex topics: Bone Tissue Engineering Materials · Advanced Photocatalysis Techniques · Polymer Surface Interaction Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry Tsinghua University Beijing 100084 China

Department of Geriatric Dentistry Beijing Laboratory of Biomedical Materials Peking University School and Hospital of Stomatology Beijing 100081 China

State Key Laboratory of Rare Earth Resource Utilization Changchun, Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

School of Chemistry and Chemical Engineering Frontiers Science Centre for Transformative Molecules Institute of Translational Medicine and Institute of Molecular Medicine Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200240 China

Department of Orthodontics Cranial‐Facial Growth and Development Center Peking University School and Hospital of Stomatology Beijing 100081 China

Institute of Process Equipment College of Energy Engineering and State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University Hangzhou 310027 China

Funding

National Natural Science Foundation of China

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