journal article·2022-04

Star‐Polymer–DNA Gels Showing Highly Predictable and Tunable Mechanical Responses

Masashi Ohira, Takuya Katashima, Mitsuru Naito, Daisuke Aoki, Yusuke Yoshikawa, Hiroki Iwase, Shin‐ichi Takata, Kanjiro Miyata, Ung‐il Chung, Takamasa Sakai, Mitsuhiro Shibayama, Xiang Li

Advanced Materials· Volume 34· Issue 13
Publisher page

Abstract

Abstract Dynamically crosslinked gels are appealing materials for applications that require time‐dependent mechanical responses. DNA duplexes are ideal crosslinkers for building such gels because of their excellent sequence addressability and flexible tunability in bond energy. However, the mechanical responses of most DNA gels are complicated and unpredictable. Here, a DNA gel with a highly homogeneous gel network and well predictable mechanical behaviors is demonstrated by using a pair of star‐polymer–DNA precursors with presimulated DNA sequences showing the two‐state transition. The melting curve analysis of the DNA gels reveals the good correspondence between the thermodynamic potentials of the DNA crosslinkers and the presimulated values by DNA calculators. Stress‐relaxation tests and dissociation kinetics measurements show that the macroscopic relaxation time of the DNA gels is approximately equal to the lifetime of the DNA crosslinkers over 4 orders of magnitude from 0.1–2000 s. Furthermore, a series of durability tests find the DNA gels are hysteresis‐less and self‐healable after the applications of repeated temperature and mechanical stimuli. These results demonstrate the great potential of star‐polymer–DNA precursors for building gels with predictable and tunable viscoelastic properties, suitable for applications such as stress‐response extracellular matrices, injectable solids, and soft robotics.
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Research context

OpenAlex topics: Hydrogels: synthesis, properties, applications · Advanced Materials and Mechanics · Surface Modification and Superhydrophobicity

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Bioengineering Graduate School of Engineering The University of Tokyo 7‐3‐1 Hongo Bunkyo‐ku Tokyo 113–8685 Japan

Center for Disease Biology and Integrative Medicine Graduate School of Medicine The University of Tokyo 7‐3‐1 Hongo Bunkyo‐ku Tokyo 113‐0033 Japan

Department of Chemical Science and Engineering Tokyo Institute of Technology 2‐12‐1 Ookayama Meguro‐ku Tokyo 152–8550 Japan

Neutron Science Laboratory Institute for Solid State Physics The University of Tokyo 5‐1‐5 Kashiwanoha Kashiwa Chiba 277–8581 Japan

Neutron Science and Technology Center Comprehensive Research Organization for Science and Society (CROSS) 162‐1 Shirakata Tokai Naka Ibaraki 319–1106 Japan

Materials and Life Science Division J‐PARC Center Japan Atomic Energy Agency (JAEA) 2–4 Shirakata Tokai Ibaraki 319–1195 Japan

Department of Materials Engineering Graduate School of Engineering The University of Tokyo 7‐3‐1 Hongo Bunkyo‐ku Tokyo 113–8656 Japan

Faculty of Advanced Life Science Hokkaido University Sapporo 001–0021 Japan

Funding

Center of Innovation Program · Core Research for Evolutional Science and Technology · Japan Science and Technology Agency · Japan Society for the Promotion of Science

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