DataVXAdvanced MaterialsPaper
journal article·2022-12

Photoswitchable Microgels for Dynamic Macrophage Modulation

Yuri Kim, Ramar Thangam, Jounghyun Yoo, Jeongyun Heo, Jung Yeon Park, Nayeon Kang, Sungkyu Lee, Jiwon Yoon, Kwang Rok Mun, Misun Kang, Sunhong Min, Seong Yeol Kim, Subin Son, Jihwan Kim, Hyunsik Hong, Gunhyu Bae, Kanghyeon Kim, Sanghyeok Lee, Letao Yang, Ja Yeon Lee, Jinjoo Kim, Steve Park, Dong‐Hyun Kim, Ki‐Bum Lee, Woo Young Jang, Bong Hoon Kim, Ramasamy Paulmurugan, Seung‐Woo Cho, Hyun‐Cheol Song, Seok Ju Kang, Wujin Sun, Yangzhi Zhu, Junmin Lee, Han‐Jun Kim, Ho Seong Jang, Jong Seung Kim, Ali Khademhosseini, Yongju Kim, Sehoon Kim, Heemin Kang

Advanced Materials· Volume 34· Issue 49
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Source abstract

Abstract

Abstract Dynamic manipulation of supramolecular self‐assembled structures is achieved irreversibly or under non‐physiological conditions, thereby limiting their biomedical, environmental, and catalysis applicability. In this study, microgels composed of azobenzene derivatives stacked via π–cation and π–π interactions are developed that are electrostatically stabilized with Arg–Gly–Asp (RGD)‐bearing anionic polymers. Lateral swelling of RGD‐bearing microgels occurs via cis‐azobenzene formation mediated by near‐infrared‐light‐upconverted ultraviolet light, which disrupts intermolecular interactions on the visible‐light‐absorbing upconversion‐nanoparticle‐coated materials. Real‐time imaging and molecular dynamics simulations demonstrate the deswelling of RGD‐bearing microgels via visible‐light‐mediated trans‐azobenzene formation. Near‐infrared light can induce in situ swelling of RGD‐bearing microgels to increase RGD availability and trigger release of loaded interleukin‐4, which facilitates the adhesion structure assembly linked with pro‐regenerative polarization of host macrophages. In contrast, visible light can induce deswelling of RGD‐bearing microgels to decrease RGD availability that suppresses macrophage adhesion that yields pro‐inflammatory polarization. These microgels exhibit high stability and non‐toxicity. Versatile use of ligands and protein delivery can offer cytocompatible and photoswitchable manipulability of diverse host cells.
Source: crossref · Quality: baseline

Research context

PolymersNanomaterialsCatalysis & surfaces

OpenAlex topics: Photochromic and Fluorescence Chemistry · Nanoplatforms for cancer theranostics · Supramolecular Self-Assembly in Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Materials Science and Engineering Korea University Seoul 02841 Republic of Korea

Institute for High Technology Materials and Devices Korea University Seoul 02841 Republic of Korea

Chemical and Biological Integrative Research Center Korea Institute of Science and Technology Seoul 02792 Republic of Korea

KU‐KIST Graduate School of Converging Science and Technology Korea University Seoul 02841 Republic of Korea

Materials Architecturing Research Center Korea Institute of Science and Technology Seoul 02792 Republic of Korea

Department of Chemistry Korea University Seoul 02841 Republic of Korea

Department of Chemistry and Chemical Biology Rutgers University Piscataway NJ 08854 USA

Terasaki Institute for Biomedical Innovation Los Angeles CA 90024 USA

Department of Materials Science and Engineering Korea Advanced Institute of Science and Technology (KAIST) Daejeon 34141 Republic of Korea

Department of Radiology Feinberg School of Medicine Northwestern University Chicago IL 60611 USA

Department of Orthopedic Surgery Korea University Anam Hospital Seoul 02841 Republic of Korea

Daegu Gyeongbuk Institute of Science and Technology (DGIST) Department of Robotics and Mechatronics Engineering Daegu 42988 Republic of Korea

Department of Radiology Molecular Imaging Program at Stanford Stanford University School of Medicine Stanford University Palo Alto CA 94304 USA

Department of Radiology Canary Center at Stanford for Cancer Early Detection Stanford University School of Medicine Stanford University Palo Alto CA 94304 USA

Department of Biotechnology Yonsei University Seoul 03722 Republic of Korea

Center for Nanomedicine Institute for Basic Science (IBS) Seoul 03722 Republic of Korea

Electronic Materials Research Center Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of Korea

KIST‐SKKU Carbon‐Neutral Research Center Sungkyunkwan University (SKKU) Suwon 16419 Republic of Korea

School of Energy and Chemical Engineering Ulsan National Institute of Science and Technology (UNIST) Ulsan 44919 Republic of Korea

Department of Biological Systems Engineering Virginia Tech Blacksburg VA 24061 USA

Department of Materials Science and Engineering Pohang University of Science and Technology (POSTECH) Pohang 37673 Republic of Korea

Division of Nano & Information Technology KIST School Korea University of Science and Technology (UST) Seoul 02792 Republic of Korea

College of Medicine Korea University Seoul 02841 Republic of Korea

Funding

National Research Foundation of Korea · Korea University · Korea Basic Science Institute

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