DataVXAdvanced MaterialsPaper
journal article·2024-05Open access

Strontium‐Containing Piezoelectric Biofilm Promotes Dentin Tissue Regeneration

Jin Li, Xuefeng Zhao, Yang Xia, Xuanyu Qi, Chenghao Jiang, Yuhuan Xiao, Fei Jiang, Xinquan Jiang, Guoliang Yuan

Advanced Materials· Volume 36· Issue 21
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Source abstract

Abstract

Abstract It remains an obstacle to induce the regeneration of hard dentin tissue in clinical settings. To overcome this, a P(VDF‐TrFE) piezoelectric film with 2 wt% SrCl2 addition is designed. The biofilm shows a high flexibility, a harmonious biocompatibility, and a large piezoelectric d33 coefficient of 14 pC N−1, all contributing to building an electric microenvironment that favor the recruitment of dental pulp stem cells (DPSCs) and their differentiation into odontoblasts during normal chewing, speaking, etc. On the other hand, the strontium ions can be gradually released from the film, thus promoting DPSC odonto‐differentiation. In vivo experiments also demonstrate that the film induces the release of dentin minerals and regeneration of dentin tissue. In the large animal dentin defect models, this piezoelectric film induces in situ dentin tissue formation effectively over a period of three months. This study illustrates a therapeutic potential of the piezoelectric film to improve dentin tissue repair in clinical settings.
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Research context

Biomaterials

OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Electrospun Nanofibers in Biomedical Applications · Tissue Engineering and Regenerative Medicine

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Jiangsu Key Laboratory of Oral Diseases Jiangsu Province Engineering Research Center of Stomatological Translational Medicine Department of General Dentistry Affiliated Hospital of Stomatology Nanjing Medical University Nanjing 210029 P. R. China

School of Materials Science and Engineering Nanjing University of Science and Technology. No. 200 Xiaolingwei Street Nanjing 210094 China

Jiangsu Key Laboratory of Oral Diseases Jiangsu Province Engineering Research Center of Stomatological Translational Medicine Nanjing Medical University Department of Prosthodontics Affiliated Hospital of Stomatology Nanjing Medical University Nanjing 210029 P. R. China

College of Stomatology Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai Engineering Research Center of Advanced Dental Technology and Materials Shanghai 200011 China

Funding

National Natural Science Foundation of China · Priority Academic Program Development of Jiangsu Higher Education Institutions · Innovative Research Team of High-level Local University in Shanghai

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