DataVXAdvanced MaterialsPaper
journal article·2022-02

Reconstructable Uterus‐Derived Materials for Uterus Recovery toward Efficient Live Births

Xiao Yi, Fan Liu, Kunjie Gao, Feng Chen, Yifeng Wang, Huayan Li, Xuefeng Wang, Yi Huang, Huijiao Fu, Weijie Zhou, Jun‐Bing Fan, Shutao Wang, Yi Gao

Advanced Materials· Volume 34· Issue 8
Publisher page
Source abstract

Abstract

Abstract Uterine factor infertility is increasingly common in modern society and has severely affected human life and health. However, the existing biomaterial scaffold‐mediated systems remain limited in efficient uterus recovery, leading to low pregnancy rate and live births. Here, reconstructable uterus‐derived materials (RUMs) are demonstrated by combining uterus‐derived extracellular matrix and seeded chorionic villi mesenchymal stem cells for uterus recovery, achieving highly efficient live births in rats with severe uterine injury. The RUMs can be designed into different states (such as, liquid RUMs and solid RUMs) and shapes (such as, cuboid, triangular‐prism, and cube) in terms of requirements. The RUMs can effectively prevent intrauterine adhesion, and promote endometrial regeneration and muscle collagen reconstruction, as well as, accelerate wound healing by constructing a physical barrier and secreting cytokines, allowing efficient uterus recovery. The injured uterus nearly achieves complete recovery after treating with the RUMs and has normal pregnancies for supporting fetal development and live births, similar to the normal rats. The study provides a regenerative medicine therapeutics for uterine factor infertility.
Source: crossref · Quality: baseline

Research context

Biomaterials

OpenAlex topics: Uterine Myomas and Treatments · Reproductive System and Pregnancy · Endometriosis Research and Treatment

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Research Centre for Artificial Organ and Tissue Engineering & Institute of Regenerative Medicine Department of Hepatobiliary Surgery II Zhujiang Hospital Cancer Research Institute School of Basic Medical Sciences Southern Medical University Guangzhou Guangdong Province 510280 P. R. China

Department of Gynecology Zhujiang Hospital Southern Medical University Guangzhou Guangdong Province P. R. China

Department of Gynecology The Third Affiliated Hospital of Southern Medical University Guangzhou Guangdong P. R. China

Department of Gynecology Nanhai People's Hospital Southern Medical University Guangzhou Guangdong Province P. R. China

Department of Pathology School of Basic Medical Sciences Southern Medical University Guangzhou Guangdong 510515 P. R. China

CAS Key Laboratory of Bio‐inspired Materials and Interfacial Science, CAS Center for Excellence in Nanoscience, Technical Institute of Physics and Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province

References (38)

Show source-provided references
1. 10.1038/240475a010.1038/240475a0 ↗
2. 10.1056/NEJMra00076310.1056/NEJMra000763 ↗
3. 10.1038/nature0856210.1038/nature08562 ↗
4. 10.1038/s41563-020-00829-910.1038/s41563-020-00829-9 ↗
5. 10.1038/s41587-020-0547-710.1038/s41587-020-0547-7 ↗
6. Bosteels J. · Cochrane Db. Syst. Rev. · 2015 · 11
7. Zhu R. · BioMed. Res. Int. · 2018 · 2018 · 1
8. 10.1016/j.jmig.2013.07.01810.1016/j.jmig.2013.07.018 ↗
9. 10.1038/nrendo.2016.11610.1038/nrendo.2016.116 ↗
10. 10.1016/j.mtbio.2021.10010110.1016/j.mtbio.2021.100101 ↗
11. 10.1126/sciadv.aba635710.1126/sciadv.aba6357 ↗
12. 10.1002/adma.20200547610.1002/adma.202005476 ↗
13. 10.1002/adma.20140555610.1002/adma.201405556 ↗
14. 10.1038/s41573-021-00175-810.1038/s41573-021-00175-8 ↗
15. 10.1016/j.fertnstert.2016.03.04810.1016/j.fertnstert.2016.03.048 ↗
16. 10.1002/adma.20190058210.1002/adma.201900582 ↗
17. 10.1095/biolre/bio14339610.1095/biolre/bio143396 ↗
18. 10.1002/adma.20130460710.1002/adma.201304607 ↗
19. 10.1038/s41551-019-0500-610.1038/s41551-019-0500-6 ↗
20. 10.1038/3027010.1038/30270 ↗
21. 10.1126/sciadv.abb635110.1126/sciadv.abb6351 ↗
22. 10.1126/science.117600910.1126/science.1176009 ↗
23. 10.1038/s41586-020-2612-210.1038/s41586-020-2612-2 ↗
24. 10.1038/natrevmats.2015.1210.1038/natrevmats.2015.12 ↗
25. 10.1038/s41467-019-12545-310.1038/s41467-019-12545-3 ↗
26. 10.1016/j.biomaterials.2014.06.05210.1016/j.biomaterials.2014.06.052 ↗
27. 10.1186/s13287-017-0535-010.1186/s13287-017-0535-0 ↗
28. 10.1007/s10439-016-1783-310.1007/s10439-016-1783-3 ↗
29. 10.1016/j.biomaterials.2014.02.04610.1016/j.biomaterials.2014.02.046 ↗
30. 10.1007/s43032-021-00503-810.1007/s43032-021-00503-8 ↗
31. 10.1002/adfm.20210335510.1002/adfm.202103355 ↗
32. 10.1186/s13287-020-01690-y10.1186/s13287-020-01690-y ↗
33. 10.1016/j.cell.2013.12.02510.1016/j.cell.2013.12.025 ↗
34. 10.1101/gad.9.18.226610.1101/gad.9.18.2266 ↗
35. 10.1016/j.tips.2020.06.00910.1016/j.tips.2020.06.009 ↗
36. 10.1038/cr.2010.4410.1038/cr.2010.44 ↗
37. 10.1038/nri.2016.4910.1038/nri.2016.49 ↗
38. 10.1002/adhm.20190041110.1002/adhm.201900411 ↗