journal article·2022-05Open access

A Readily Scalable, Clinically Demonstrated, Antibiofouling Zwitterionic Surface Treatment for Implantable Medical Devices

Brian McVerry, Alexandra Polasko, Ethan Rao, Reihaneh Haghniaz, Dayong Chen, Na He, Pia Ramos, Joel Hayashi, Paige Curson, Chueh‐Yu Wu, Praveen Bandaru, Mackenzie Anderson, Brandon Bui, Aref Sayegh, Shaily Mahendra, Dino Di Carlo, Evgeniy Kreydin, Ali Khademhosseini, Amir Sheikhi, Richard B. Kaner

Advanced Materials· Volume 34· Issue 20

Abstract

Abstract Unlike growth on tissue, microbes can grow freely on implantable devices with minimal immune system intervention and often form resilient biofilms that continuously pump out pathogenic cells. The efficacy of antibiotics used to treat infection is declining due to increased rates of pathogenic resistance. A simple, one‐step zwitterionic surface modification is developed to significantly reduce protein and microbial adhesion to synthetic materials and demonstrate the successful modification of several clinically relevant materials, including recalcitrant materials such as elastomeric polydimethylsiloxane. The treated surfaces exhibit robust adhesion resistance against proteins and microorganisms in both static and flow conditions. Furthermore, the surface treatment prevents the adhesion of mammalian fibroblast cells while displaying no cytotoxicity. To demonstrate the clinical efficacy of the novel technology in the real‐world, a surface‐treated, commercial silicone foley catheter is developed that is cleared for use by the U.S. Food and Drug Administration (K192034). 16 long‐term catheterized patients received surface‐treated catheters and completed a Patient Global Impression of Improvement (PGI‐I) questionnaire. 10 out of 16 patients described their urinary tract condition post implantation as “much better” or “very much better” and 72% (n = 13) of patients desire to continue using the surface‐treated catheter over conventional latex or silicone catheters.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Polymer Surface Interaction Studies · Bone Tissue Engineering Materials · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry and Biochemistry University of California Los Angeles CA 90095 USA

Silq Technologies, Corp. Los Angeles CA 90025 USA

Department of Civil and Environmental Engineering University of California Los Angeles CA 90095 USA

Center for Minimally Invasive Therapeutics (C‐MIT) University of California, Los Angeles Los Angeles CA 90095 USA

California NanoSystems Institute (CNSI) University of California, Los Angeles Los Angeles CA 90095 USA

Department of Materials Science and Engineering University of California Los Angeles CA 90095 USA

Department of Bioengineering University of California, Los Angeles Los Angeles CA 90095 USA

Department of Urology Keck School of Medicine of University of Southern California Los Angeles CA 90033 USA

Rancho Research Institute Rancho Los Amigos National Rehabilitation Center Downey CA 90242 USA

Department of Radiological Sciences David Geffen School of Medicine University of California – Los Angeles Los Angeles CA 90095 USA

Department of Chemical and Biomolecular Engineering University of California, Los Angeles Los Angeles CA 90095 USA

Department of Bioindustrial Technologies College of Animal Bioscience and Technology Konkuk University Seoul 143‐701 Republic of Korea

Department of Chemical Engineering The Pennsylvania State University University Park PA 16802 USA

Department of Biomedical Engineering The Pennsylvania State University University Park PA 16802 USA

Funding

National Institutes of Health

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