DataVXAdvanced MaterialsPaper
journal article·2018-12

A Fully 3D Interconnected Graphene–Carbon Nanotube Web Allows the Study of Glioma Infiltration in Bioengineered 3D Cortex‐Like Networks

Miao Xiao, Xiaoyun Li, Qin Song, Qi Zhang, Marco Lazzarino, Guosheng Cheng, Francesco Paolo Ulloa Severino, Vincent Torre

Advanced Materials· Volume 30· Issue 52
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Source abstract

Abstract

Abstract Currently available 3D assemblies based on carbon nanotubes (CNTs) lag far behind their 2D CNT‐based bricks and require major improvements for biological applications. By using Fe nanoparticles confined to the interlamination of graphite as catalyst, a fully 3D interconnected CNT web is obtained through the pores of graphene foam (GCNT web) by in situ chemical vapor deposition. This 3D GCNT web has a thickness up to 1.5 mm and a completely geometric, mechanical and electrical interconnectivity. Dissociated cortical cells cultured inside the GCNT web form a functional 3D cortex‐like network exhibiting a spontaneous electrical activity that is closer to what is observed in vivo. By coculturing and fluorescently labeling glioma and healthy cortical cells with different colors, a new in vitro model is obtained to investigate malignant glioma infiltration. This model allows the 3D trajectories and velocity distribution of individual infiltrating glioma to be reconstructed with an unprecedented precision. The model is cost effective and allows a quantitative and rigorous screening of anticancer drugs. The fully 3D interconnected GCNT web is biocompatible and is an ideal tool to study 3D biological processes in vitro representing a pivotal step toward precise and personalized medicine.
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Research context

NanomaterialsBiomaterialsCatalysis & surfacesMaterials processing

OpenAlex topics: Graphene and Nanomaterials Applications · Neuroscience and Neural Engineering · 3D Printing in Biomedical Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

International School for Advanced Studies (SISSA) via Bonomea 265 Trieste 34136 Italy

Joint Laboratory of Biophysics and Translational Medicine ISM‐SISSA Suzhou Industrial Park Jiangsu 215123 China

Cixi Institute of Biomedical Engineering Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Zhejiang 315201 China

School of Pharmaceutical Engineering Zhejiang Pharmaceutical College Ningbo Zhejiang 315100 China

School for Radiological and Interdisciplinary Sciences (RAD‐X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Medical College of Soochow University Suzhou Industrial Park Suzhou Jiangsu 215123 China

IOM‐CNR Area Science Park Basovizza Trieste 34149 Italy

CAS Key Laboratory of Nano‐Bio Interface Suzhou Institute of Nano‐Tech and Nano‐Bionics Chinese Academy of Sciences 398 Ruoshui Road, Suzhou Industrial Park Jiangsu 215123 China

Cell Biology Department Duke University Medical Center 335 Nanaline Duke Building Duke University Medical Center Durham NC 27710 USA

Funding

Natural Science Foundation of Zhejiang Province · Natural Science Foundation of Ningbo Municipality

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