A Nanozyme‐Based Electrode for High‐Performance Neural Recording

Abstract Implanted neural electrodes have been widely used to treat brain diseases that require high sensitivity and biocompatibility at the tissue–electrode interface. However, currently used clinical electrodes cannot meet both these requirements simultaneously, which hinders the effective recording of electronic signals. Herein, nanozyme‐based neural electrodes incorporating bioinspired atomically precise clusters are developed as a general strategy with a heterogeneous design for multiscale and ultrasensitive neural recording via quantum transport and biocatalytic processes. Owing to the dual high‐speed electronic and ionic currents at the electrode–tissue interface, the impedance of nanozyme electrodes is 26 times lower than that of state‐of‐the‐art metal electrodes, and the acquisition sensitivity for the local field potential is ≈10 times higher than that of clinical PtIr electrodes, enabling a signal‐to‐noise ratio (SNR) of up to 14.7 dB for single‐neuron recordings in rats. The electrodes provide more than 100‐fold higher antioxidant and multi‐enzyme‐like activities, which effectively decrease 67% of the neuronal injury area by inhibiting glial proliferation and allowing sensitive and stable neural recording. Moreover, nanozyme electrodes can considerably improve the SNR of seizures in acute epileptic rats and are expected to achieve precise localization of seizure foci in clinical settings.