DataVXAdvanced MaterialsPaper
journal article·2021-09

A Soft and Absorbable Temporary Epicardial Pacing Wire

Chen Hang, Li Ding, Shiyu Cheng, Ruihua Dong, Jie Qi, Xiaoyan Liu, Qian Liu, Yan Zhang, Xingyu Jiang

Advanced Materials· Volume 33· Issue 36
Publisher page
Source abstract

Abstract

Abstract Existing temporary epicardial pacing wires (TPWs) are rigid and non‐absorbable, such that they can cause severe complications after cardiac surgery. Here, a soft and absorbable temporary epicardial pacing wire (saTPW) for effectively correcting abnormal heart rates in a rabbit model, such as bradycardia and ventricular premature beat, is developed. The saTPW exhibits excellent conductivity, flexibility, cycling stability (>100 000 cycles), and less inflammatory response during two‐month subcutaneous implantation in a rat model. The saTPW which consists of poly(l‐lactide‐co‐ε‐caprolactone) and liquid metal, can degrade about 13% (mass loss) in the rats over a two‐month subcutaneous implantation. It can be absorbed over time in the body. The cytocompatibility and absorbability avoid secondary injuries caused by remaining wires which are permanently left in the body. The saTPW will provide a great platform for diagnosis and treatments in cardiovascular diseases by delivering the physiological signal and applying electrical stimulation for therapy.
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Research context

Biomaterials

OpenAlex topics: Cardiac pacing and defibrillation studies · Advanced Sensor and Energy Harvesting Materials · Neuroscience and Neural Engineering

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Shenzhen Key Laboratory of Smart Healthcare Engineering Department of Biomedical Engineering Southern University of Science and Technology No. 1088, Xueyuan Rd., Xili, Nanshan District Shenzhen Guangdong 518055 P. R. China

Chinese Academy of Sciences (CAS) Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for NanoScience and Technology No. 11 Zhongguancun Beiyitiao Beijing 100190 P. R. China

University of Chinese Academy of Sciences 19 A Yuquan Road, Shijingshan District Beijing 100049 P. R. China

State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100037 China

Funding

National Natural Science Foundation of China · Chinese Academy of Sciences

References (37)

Show source-provided references
1. 10.1161/01.CIR.37.4S2.II-17810.1161/01.CIR.37.4S2.II-178 ↗
2. 10.1111/j.1365-2044.2007.04950.x10.1111/j.1365-2044.2007.04950.x ↗
3. 10.1136/hrt.81.1.8810.1136/hrt.81.1.88 ↗
4. 10.1016/S0003-4975(03)01141-X10.1016/S0003-4975(03)01141-X ↗
5. 10.1016/j.athoracsur.2008.03.01310.1016/j.athoracsur.2008.03.013 ↗
6. 10.1093/eurheartj/ehw06310.1093/eurheartj/ehw063 ↗
7. 10.1016/j.athoracsur.2006.04.04010.1016/j.athoracsur.2006.04.040 ↗
8. 10.1038/s41467-019-13637-w10.1038/s41467-019-13637-w ↗
9. 10.1038/s41467-019-09851-110.1038/s41467-019-09851-1 ↗
10. 10.1038/s41551-018-0336-510.1038/s41551-018-0336-5 ↗
11. 10.1002/adma.20150253510.1002/adma.201502535 ↗
12. 10.1038/s41928-020-00493-610.1038/s41928-020-00493-6 ↗
13. 10.1073/pnas.200020711710.1073/pnas.2000207117 ↗
14. 10.1038/s41551-020-00604-w10.1038/s41551-020-00604-w ↗
15. 10.1038/s41551-018-0335-610.1038/s41551-018-0335-6 ↗
16. 10.1038/s41467-020-19660-610.1038/s41467-020-19660-6 ↗
17. 10.1038/s41467-020-18977-610.1038/s41467-020-18977-6 ↗
18. 10.1038/s41467-020-18214-010.1038/s41467-020-18214-0 ↗
19. 10.1038/s41467-019-14054-910.1038/s41467-019-14054-9 ↗
20. 10.1126/science.abc973510.1126/science.abc9735 ↗
21. 10.1038/s41467-020-20016-310.1038/s41467-020-20016-3 ↗
22. 10.1038/s41467-020-17619-110.1038/s41467-020-17619-1 ↗
23. 10.1039/C7CS00309A10.1039/C7CS00309A ↗
24. 10.1126/sciadv.abe377810.1126/sciadv.abe3778 ↗
25. 10.1038/ncomms1006610.1038/ncomms10066 ↗
26. 10.1007/s11434-016-1090-210.1007/s11434-016-1090-2 ↗
27. 10.1021/acsami.8b2046010.1021/acsami.8b20460 ↗
28. 10.1039/C9MH01761E10.1039/C9MH01761E ↗
29. 10.1002/smll.20200533610.1002/smll.202005336 ↗
30. 10.1016/j.matt.2020.08.02910.1016/j.matt.2020.08.029 ↗
31. 10.1021/acsnano.0c0482710.1021/acsnano.0c04827 ↗
32. Dong R. · Adv. Healthcare Mater. · 2020 · 11
33. 10.1002/adma.20170017110.1002/adma.201700171 ↗
34. 10.1093/ejcts/ezu33410.1093/ejcts/ezu334 ↗
35. 10.1016/j.jtcvs.2010.05.05810.1016/j.jtcvs.2010.05.058 ↗
36. 10.5834/jdh.37.36110.5834/jdh.37.361 ↗
37. Castronovo F. P. · Br. J. Exp. Pathol. · 1971 · 52 · 543