DataVXAdvanced MaterialsPaper
journal article·2024-07

Ultrasmall Polyphenol‐NAD+ Nanoparticle‐Mediated Renal Delivery for Mitochondrial Repair and Anti‐Inflammatory Treatment of AKI‐to‐CKD Progression

Ying Kong, Xu Chen, Feng Liu, Jiageng Tang, Yijing Zhang, Xiangxiang Zhang, Luyao Zhang, Tong Zhang, Yaqi Wang, Mengxiao Su, Qixin Zhang, Hanxiang Chen, Di Zhou, Fan Yi, Hong Liu, Yi Fu

Advanced Materials· Volume 36· Issue 30
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Source abstract

Abstract

Abstract As a central metabolic molecule, nicotinamide adenine dinucleotide (NAD+) can potentially treat acute kidney injury (AKI) and chronic kidney disease (CKD); however, its bioavailability is poor due to short half‐life, instability, the deficiency of targeting, and difficulties in transmembrane transport. Here a physiologically adaptive gallic acid‐NAD+ nanoparticle is designed, which has ultrasmall size and pH‐responsiveness, passes through the glomerular filtration membrane to reach injured renal tubules, and efficiently delivers NAD+ into the kidneys. With an effective accumulation in the kidneys, it restores renal function, immune microenvironment homeostasis, and mitochondrial homeostasis of AKI mice via the NAD+‐Sirtuin‐1 axis, and exerts strong antifibrotic effects on the AKI‐to‐CKD transition by inhibiting TGF‐β signaling. It also exhibits excellent stability, biodegradable, and biocompatible properties, ensuring its long‐term safety, practicality, and clinical translational feasibility. The present study shows a potential modality of mitochondrial repair and immunomodulation through nanoagents for the efficient and safe treatment of AKI and CKD.
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Research context

NanomaterialsBiomaterials

OpenAlex topics: Acute Kidney Injury Research · Renal Transplantation Outcomes and Treatments · Organ Transplantation Techniques and Outcomes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Nephrology The First Affiliated Hospital of Shandong First Medical University NHC Key Laboratory of Biotechnology Drugs (Shandong Academy of Medical Sciences) Key Lab for Rare & Uncommon Diseases of Shandong Province Shandong First Medical University & Shandong Academy of Medical Sciences Jinan 250117 Shandong China

State Key Laboratory of Crystal Materials Shandong University Jinan 250100 Shandong China

Biomedical Sciences College & Shandong Medicinal Biotechnology Centre Shandong First Medical University & Shandong Academy of Medical Sciences Jinan 250117 Shandong China

Department of Clinical Laboratory The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital Jinan 250014 Shandong China

Department of Pharmacy The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Hefei 230001 Anhui China

Department of Pharmacology School of Basic Medical Science Shandong University Jinan 250012 Shandong China

National Key Laboratoy for innovation and Transfomation of Luobing Theoy, Key Laboratory of Cardiovascular Health, Qilu Hospital Shandong University Jinan 250012 Shandong China

Institute for Advanced Interdisciplinary Research (iAIR) University of Jinan Jinan 250022 Shandong China

Funding

National Natural Science Foundation of China · China Postdoctoral Science Foundation · Natural Science Foundation of Shandong Province

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