journal article·2022-01

Chirality Bias Tissue Homeostasis by Manipulating Immunological Response

Shengjie Jiang, Qiang Zeng, Kai Zhao, Jinying Liu, Qiannan Sun, Kang Huang, Ying He, Xuehui Zhang, Hui Wang, Xinghua Shi, Chuanliang Feng, Xuliang Deng, Yan Wei

Advanced Materials· Volume 34· Issue 2
Publisher page

Abstract

Abstract The physiological chirality of extracellular environments is substantially affected by pathological diseases. However, how this stereochemical variation drives host immunity remains poorly understood. Here, it is reported that pathology‐mimetic M‐nanofibrils—but not physiology‐mimetic P‐nanofibrils—act as a defense mechanism that helps to restore tissue homeostasis by manipulating immunological response. Quantitative multi‐omics in vivo and in vitro shows that M‐nanofibrils significantly inhibit inflammation and promote tissue regeneration by upregulating M2 macrophage polarization and downstream immune signaling compared with P‐nanofibrils. Molecular analysis and theoretical simulation demonstrate that M‐chirality displays higher stereo‐affinity to cellular binding, which induces higher cellular contractile stress and activates mechanosensitive ion channel PIEZOl to conduct Ca2+ influx. In turn, the nuclear transfer of STAT is biased by Ca2+ influx to promote M2 polarization. These findings underscore the structural mechanisms of disease, providing design basis for immunotherapy with bionic functional materials.
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Research context

OpenAlex topics: Lipid Membrane Structure and Behavior · RNA Interference and Gene Delivery · Immune cells in cancer

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Beijing Laboratory of Biomedical Materials Department of Geriatric Dentistry Peking University School and Hospital of Stomatology Beijing 100081 P. R. China

Institute of Medical Technology Peking University Health Science Center Beijing 100191 P. R. China

Key Laboratory for Special Functional Materials of Ministry of Education School of Materials Science and Engineering Henan University Kaifeng 475004 P. R. China

CAS Key Laboratory of Nanosystem and Hierarchical Fabrication Laboratory of Theoretical and Computational Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 P. R. China

Department of Dental Materials and Dental Medical Devices Testing Center National Engineering Laboratory for Digital and Material Technology of Stomatology Peking University School and Hospital of Stomatology Beijing 100081 P. R. China

State Key Laboratory of Metal Matrix Composites School of Materials Science and Engineering Shanghai Jiaotong University Shanghai 200240 P. R. China

Funding

National Natural Science Foundation of China

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