DataVXAdvanced MaterialsPaper
journal article·2024-10Open access

Extracellular Vesicles from Nanomedicine‐Trained Intestinal Microbiota Substitute for Fecal Microbiota Transplant in Treating Ulcerative Colitis

Menghang Zu, Ga Liu, Haiting Xu, Zhenhua Zhu, Junfeng Zhen, Baoyi Li, Xiaoxiao Shi, Mohammad‐Ali Shahbazi, Rui L. Reis, Subhas C. Kundu, Guangjun Nie, Bo Xiao

Advanced Materials· Volume 36· Issue 41
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Abstract

Abstract The biosafety concerns associated with fecal microbiota transplant (FMT) limit their clinical application in treating ulcerative colitis (UC). Gut microbiota secrete abundant extracellular vesicles (Gm‐EVs), which play a critical role in bacteria‐to‐bacteria and bacteria‐to‐host communications. Herein, intestinal microbiota are trained using tea leaf lipid/pluronic F127‐coated curcumin nanocrystals (CN@Lp127s), which can maintain stability during transit through the gastrointestinal tract. Compared with FMT, Gm‐EVs derived from healthy mice significantly improve treatment outcomes against UC by reducing colonic inflammatory responses, restoring colonic barrier function, and rebalancing intestinal microbiota. Strikingly, Gm‐EVs obtained from CN@Lp127‐trained healthy mice exhibit a superior therapeutic effect on UC compared to groups receiving FMT from healthy mice, Gm‐EVs from healthy mice, and FMT from CN@Lp127‐trained healthy mice. Oral administration of Gm‐EVs from CN@Lp127‐trained healthy mice not only alleviates colonic inflammation, promotes mucosal repair, and regulates gut microbiota but also regulates purine metabolism to decrease the uric acid level, resulting in a robust improvement in the UC. This study demonstrates the UC therapeutic efficacy of Gm‐EVs derived from nanomedicine‐trained gut microbiota in regulating the immune microenvironment, microbiota, and purine metabolism of the colon. These EVs provide an alternative platform to replace FMT as a treatment for UC.
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Research context

Nanomaterials

OpenAlex topics: Clostridium difficile and Clostridium perfringens research · Gut microbiota and health · Bacterial Infections and Vaccines

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Pharmacy Personalized Drug Therapy Key Laboratory of Sichuan Province Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital School of Medicine University of Electronic Science and Technology of China Chengdu 610054 China

State Key Laboratory of Resource Insects College of Sericulture, Textile, and Biomass Sciences Southwest University Chongqing 400715 China

Department of Gastroenterology The First Affiliated Hospital of Nanchang University Nanchang 330006 China

School of Life Sciences Southwest University Chongqing 400715 China

Department of Biomaterials and Biomedical Technology University Medical Center Groningen University of Groningen Antonius Deusinglaan 1 Groningen 9713 AV Netherlands

W.J. Kolff Institute for Biomedical Engineering and Materials Science University of Groningen Antonius Deusinglaan 1 Groningen 9713 AV Netherlands

3Bs Research Group I3Bs — Research Institute on Biomaterials Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine Barco 4805‐017 Guimarães Portugal

ICVS/3B's‐PT Government Associate Laboratory Guimarães 4800‐058 Braga Portugal

CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China

Funding

National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities · Science Fund for Distinguished Young Scholars of Chongqing Municipality · Key Science and Technology Research Project in Jiangxi Province Department of Education

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