DataVXAdvanced MaterialsPaper
journal article·2020-11Open access

Prediction of Chronic Inflammation for Inhaled Particles: the Impact of Material Cycling and Quarantining in the Lung Epithelium

Hana Kokot, Boštjan Kokot, Aleksandar Sebastijanović, Carola Voss, Rok Podlipec, Patrycja Zawilska, Trine Berthing, Carolina Ballester‐López, Pernille Høgh Danielsen, Claudia Contini, Mikhail Ivanov, Ana Krišelj, Petra Čotar, Qiaoxia Zhou, Jessica Ponti, Vadim Zhernovkov, Matthew Schneemilch, Zahra Doumandji, Mojca Pušnik, Polona Umek, Stane Pajk, Olivier Joubert, Otmar Schmid, Iztok Urbančič, Martin Irmler, Johannes Beckers, Vladimir Lobaskin, Sabina Halappanavar, Nick Quirke, Alexander P. Lyubartsev, Ulla Vogel, Tilen Koklič, Tobias Stoeger, Janez Štrancar

Advanced Materials· Volume 32· Issue 47
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Source abstract

Abstract

Abstract On a daily basis, people are exposed to a multitude of health‐hazardous airborne particulate matter with notable deposition in the fragile alveolar region of the lungs. Hence, there is a great need for identification and prediction of material‐associated diseases, currently hindered due to the lack of in‐depth understanding of causal relationships, in particular between acute exposures and chronic symptoms. By applying advanced microscopies and omics to in vitro and in vivo systems, together with in silico molecular modeling, it is determined herein that the long‐lasting response to a single exposure can originate from the interplay between the newly discovered nanomaterial quarantining and nanomaterial cycling between different lung cell types. This new insight finally allows prediction of the spectrum of lung inflammation associated with materials of interest using only in vitro measurements and in silico modeling, potentially relating outcomes to material properties for a large number of materials, and thus boosting safe‐by‐design‐based material development. Because of its profound implications for animal‐free predictive toxicology, this work paves the way to a more efficient and hazard‐free introduction of numerous new advanced materials into our lives.
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Research context

NanomaterialsMaterials processing

OpenAlex topics: Inhalation and Respiratory Drug Delivery · Air Quality and Health Impacts · Nanoparticles: synthesis and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Condensed Matter Physics Jožef Stefan Institute Ljubljana 1000 Slovenia

Jožef Stefan International Postgraduate School Ljubljana 1000 Slovenia

Faculty of Natural Sciences and Mathematics University of Maribor Maribor 2000 Slovenia

Institute of Lung Biology and Disease Helmholtz Zentrum München 85764 Neuherberg Germany

Ion Beam Center Helmholtz‐Zentrum Dresden‐Rossendorf e.V. 01328 Dresden Germany

National Research Centre for the Working Environment Copenhagen Ø 2100 Denmark

Department of Chemistry Molecular Sciences Research Hub Imperial College London London W12 0BZ UK

Department of Materials and Environmental Chemistry Stockholm University Stockholm SE‐10691 Sweden

Faculty of Mathematics and Physics University of Ljubljana Ljubljana 1000 Slovenia

Department of Forensic Pathology Sichuan University Chengdu 610065 China

European Commission Joint Research Centre (JRC) Ispra 21027 Italy

Systems Biology Ireland School of Medicine University College Dublin Belfield Dublin 4 Ireland

Institut Jean Lamour, UMR CNRS 7198 Université de Lorraine CNRS, IJL Nancy F‐54000 France

Faculty of Pharmacy University of Ljubljana Ljubljana 1000 Slovenia

Institute of Experimental Genetics Helmholtz Zentrum München 85764 Neuherberg Germany

German Center for Diabetes Research (DZD) 85764 Neuherberg Germany

Chair of Experimental Genetics, Center of Life and Food Sciences, Weihenstephan Technische Universität München 85354 Freising Germany

School of Physics University College Dublin Belfield Dublin 4 Ireland

Environmental Health Science and Research Bureau Health Canada Ottawa K1Y 0M1 Canada

Funding

Javna Agencija za Raziskovalno Dejavnost RS · China Scholarship Council · Science Foundation Ireland

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