DataVXAdvanced MaterialsPaper
journal article·2024-11

Ultrasmall Enzyodynamic PANoptosis Nano‐Inducers for Ultrasound‐Amplified Hepatocellular Carcinoma Therapy and Lung Metastasis Inhibition

Wuyang Wei, Hai Wang, Chunrong Ren, Ruxi Deng, Qiaoxi Qin, Li Ding, Pan Li, Ying Liu, Meiqi Chang, Yu Chen, Yang Zhou

Advanced Materials· Volume 36· Issue 45
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Source abstract

Abstract

Abstract Addressing the inefficiency of current therapeutic approaches for hepatocellular carcinoma is an urgent and pressing challenge. PANoptosis, a form of inflammatory programmed cell death, presents a dependable strategy for combating cancer by engaging multiple cell death pathways (apoptosis, pyroptosis, and necroptosis). In this study, an ultrasmall Bi 2 Sn 2 O 7 nanozyme with ultrasound‐magnified multienzyme‐mimicking properties is designed and engineered as a PANoptosis inducer through destroying the mitochondrial function of tumor cells and enhancing the intracellular accumulation of toxic reactive oxygen species, finally triggering the activation of PANoptosis process. The role of PANoptosis inducer has been verified by the expression of related proteins, including cleaved Caspase 3, NLRP3, N‐GSDMD, cleaved Caspase 1, p‐MLKL, and RIPK3. The inclusion of external ultrasonic irradiation significantly augments the enzyodynamic therapeutic efficiency. In vitro and in vivo antineoplastic efficacy, along with inhibition of lung metastasis, validate the benefits of the Bi 2 Sn 2 O 7 ‐mediated PANoptosis pathway. This study not only elucidates the intricate mechanisms underlying Bi 2 Sn 2 O 7 as a PANoptosis inducer, but also offers a novel perspective for the treatment of hepatocellular carcinoma.
Source: crossref · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Heme Oxygenase-1 and Carbon Monoxide · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Ultrasound Affiliated Hospital of Southwest Jiaotong University The Third People's Hospital of Chengdu Chengdu Sichuan 610031 China

Department of Gastroenterology Affiliated Hospital of Southwest Jiaotong University The Third People's Hospital of Chengdu Chengdu Sichuan 610031 China

Department of Medical Ultrasound Shanghai Tenth People's Hospital Ultrasound Research and Education Institute Shanghai Engineering Research Center of Ultrasound Diagnosis and Treatment Tongji University Cancer Center School of Medicine, Tongji University Shanghai 200072 P. R. China

Department of Ultrasound The Second Affiliated Hospital of Chongqing Medical University Chongqing 400010 China

Laboratory Center Shanghai Municipal Hospital of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Shanghai 200071 P. R. China

Materdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. China

Funding

Shanghai Shuguang Program · Key Research and Development Program of Sichuan Province · National Natural Science Foundation of China

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