DataVXAdvanced MaterialsPaper
journal article·2024-08Open access

Citric Acid: A Nexus Between Cellular Mechanisms and Biomaterial Innovations

Hui Xu, Su Yan, Ethan Gerhard, Denghui Xie, Xiaodong Liu, Bing Zhang, Dongquan Shi, Guillermo A. Ameer, Jian Yang

Advanced Materials· Volume 36· Issue 32
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Abstract

Abstract Citrate‐based biodegradable polymers have emerged as a distinctive biomaterial platform with tremendous potential for diverse medical applications. By harnessing their versatile chemistry, these polymers exhibit a wide range of material and bioactive properties, enabling them to regulate cell metabolism and stem cell differentiation through energy metabolism, metabonegenesis, angiogenesis, and immunomodulation. Moreover, the recent US Food and Drug Administration (FDA) clearance of the biodegradable poly(octamethylene citrate) (POC)/hydroxyapatite‐based orthopedic fixation devices represents a translational research milestone for biomaterial science. POC joins a short list of biodegradable synthetic polymers that have ever been authorized by the FDA for use in humans. The clinical success of POC has sparked enthusiasm and accelerated the development of next‐generation citrate‐based biomaterials. This review presents a comprehensive, forward‐thinking discussion on the pivotal role of citrate chemistry and metabolism in various tissue regeneration and on the development of functional citrate‐based metabotissugenic biomaterials for regenerative engineering applications.
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Research context

PolymersBiomaterials

OpenAlex topics: biodegradable polymer synthesis and properties · Bone Tissue Engineering Materials · Electrospun Nanofibers in Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Biomedical Engineering The Pennsylvania State University University Park PA 16802 USA

Department of Histology and Embryology School of Basic Medical Sciences Department of Orthopedic Surgery The Third Affiliated Hospital of Southern Medical University Southern Medical University Guangzhou 510515 P. R. China

Academy of Orthopedics of Guangdong Province Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases Guangzhou 510630 P. R. China

Research Center for Industries of the Future Westlake University Hangzhou Zhejiang 310030 P. R. China

School of Life Sciences Westlake University Hangzhou Zhejiang 310030 P. R. China

Westlake Laboratory of Life Sciences and Biomedicine Hangzhou Zhejiang 310030 P. R. China

Westlake Institute for Advanced Study Hangzhou Zhejiang 310030 P. R. China

Division of Sports Medicine and Adult Reconstructive Surgery Department of Orthopedic Surgery Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School 321 Zhongshan Road Nanjing Jiangsu 210008 P. R. China

Department of Biomedical Engineering Northwestern University Evanston IL 60208 USA

Center for Advanced Regenerative Engineering Northwestern University Evanston IL 60208 USA

Department of Surgery Feinberg School of Medicine Northwestern University Chicago IL 60611 USA

Biomedical Engineering Program School of Engineering Westlake University Hangzhou Zhejiang 310030 P. R. China

Funding

National Heart, Lung, and Blood Institute · National Institute of Neurological Disorders and Stroke

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