DataVXAdvanced MaterialsPaper
journal article·2023-08

Implantable Zinc–Oxygen Battery for In Situ Electrical Stimulation‐Promoted Neural Regeneration

Luhe Li, Dan Li, Yuanzhen Wang, Tingting Ye, Er He, Yiding Jiao, Lie Wang, Fangyan Li, Yiran Li, Jianxun Ding, Kai Liu, Junye Ren, Qianming Li, Jianjian Ji, Ye Zhang

Advanced Materials· Volume 35· Issue 32
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Source abstract

Abstract

Abstract Electrical stimulation is a promising strategy for treating neural diseases. However, current energy suppliers cannot provide effective power for in situ electrical stimulation. Here, an implantable tubular zinc–oxygen battery is reported as the power source for in situ electrical stimulation during the neural repair. The battery exhibited a high volumetric energy density of 231.4 mWh cm−3 based on the entire anode and cathode in vivo. Due to its superior electrochemical properties and biosafety, the battery can be directly wrapped around the nerve to provide in situ electrical stimulation with a minimal size of 0.86 mm3. The cell and animal experiments demonstrated that the zinc–oxygen battery‐based nerve tissue engineering conduit effectively promoted regeneration of the injured long‐segment sciatic nerve, proving its promising applications for powering implantable neural electronics in the future.
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Research context

Energy storageBiomaterials

OpenAlex topics: Neuroscience and Neural Engineering · EEG and Brain-Computer Interfaces · Conducting polymers and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional Materials Chemistry and Biomedicine Innovation Center Collaborative Innovation Center of Advanced Microstructures College of Engineering and Applied Sciences Nanjing University Nanjing 210023 China

Key Laboratory of Inflammation and Immunoregulation School of Medicine and Holistic Integrative Medicine Nanjing University of Chinese Medicine Nanjing 210023 China

Key Laboratory of Polymer Ecomaterials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Jiangsu Province · China Postdoctoral Science Foundation · National Postdoctoral Program for Innovative Talents · Jiangsu Postdoctoral Research Foundation

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