DataVXAdvanced MaterialsPaper
journal article·2021-03

Targeted Dual Small Interfering Ribonucleic Acid Delivery via Non‐Viral Polymeric Vectors for Pulmonary Fibrosis Therapy

Qijian Ji, Jiwei Hou, Xueqing Yong, Guangming Gong, Mohd. Muddassir, Tianyu Tang, Jinbing Xie, Wenpei Fan, Xiaoyuan Chen

Advanced Materials· Volume 33· Issue 12
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Source abstract

Abstract

Abstract Inhibiting the myofibroblast differentiation of lung‐resident mesenchymal stem cells (LR‐MSCs) is a promising yet challenging approach for pulmonary fibrosis (PF) therapy. Here, micelles formed by a graft copolymer of multiple PEGs modified branched polyethylenimine are used for delivering runt‐related transcription factor‐1 (RUNX1) small interfering RNA (siRNA) (siRUNX1) to the lung, aiming to inhibit the myofibroblast differentiation of LR‐MSCs. LR‐MSC targeting is achieved by functionalizing the micelle surface with an anti‐stem‐cell antigen‐1 antibody fragment (Fab′). Consequently, therapeutic benefits are obtained by successful suppression of myofibroblast differentiation of LR‐MSCs in bleomycin‐induced PF model mice treated with siRUNX1‐loaded micelles. Furthermore, an excellent synergistic effect of PF therapy is achieved for this micelle system loaded siRUNX1 and glioma‐associated oncogene homolog‐1 (Gli1) small interfering RNA (siGli1), a traditional anti‐PF siRNA of glioma‐associated oncogene homolog‐1. Hence, this work not only provides RUNX1 as a novel PF therapeutic target, but also as a promising dual siRNA‐loaded nanocarrier system for the therapy of PF.
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Research context

PolymersNanomaterials

OpenAlex topics: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis · Medical Imaging and Pathology Studies · Transplantation: Methods and Outcomes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Critical Care Medicine Xuyi People's Hospital 28 Hongwu Road, Xuyi Huai'an Jiangsu 211700 China

Department of Emergency Medicine Jinling Hospital Medical School of Nanjing University Nanjing Jiangsu 210002 China

Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science Medical School Nanjing University Nanjing Jiangsu 210093 China

Jiangsu Key Laboratory of Molecular Medicine Nanjing University Nanjing Jiangsu 210093 China

Department of Nuclear Science & Technology Nanjing University of Aeronautics and Astronautics Nanjing Jiangsu 211106 China

Department of Pharmaceutics Jinling Hospital Medical School of Nanjing University Nanjing Jiangsu 210002 China

Department of Chemistry College of Science King Saud University Riyadh 11451 Saudi Arabia

Jiangsu Key Laboratory of Molecular Imaging and Functional Imaging Department of Radiology Zhongda Hospital Medical School Southeast University 87 Dingjiaqiao Road Nanjing Jiangsu 210009 China

State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Drug Discovery for Metabolic Diseases Center of Advanced Pharmaceuticals and Biomaterials China Pharmaceutical University Nanjing Jiangsu 210009 China

Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore 119228 Singapore

Funding

National Basic Research Program of China · National Natural Science Foundation of China

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