The Landscape of Biomimetic Nanovesicles in Brain Diseases
Source abstract
Abstract
Abstract Brain diseases, such as brain tumors, neurodegenerative diseases, cerebrovascular diseases, and brain injuries, are caused by various pathophysiological changes, which pose a serious health threat. Brain disorders are often difficult to treat due to the presence of the blood–brain barrier (BBB). Biomimetic nanovesicles (BNVs), including endogenous extracellular vesicles (EVs) derived from various cells and artificial nanovesicles, possess the ability to penetrate the BBB and thus can be utilized for drug delivery to the brain. BNVs, especially endogenous EVs, are widely distributed in body fluids and usually carry various disease‐related signal molecules such as proteins, RNA, and DNA, and may also be analyzed to understand the etiology and pathogenesis of brain diseases. This review covers the exhaustive classification and characterization of BNVs and pathophysiological roles involved in various brain diseases, and emphatically focuses on nanotechnology‐integrated BNVs for brain disease theranostics, including various diagnosis strategies and precise therapeutic regulations (e.g., immunity regulation, disordered protein clearance, anti‐neuroinflammation, neuroregeneration, angiogenesis, and the gut–brain axis regulation). The remaining challenges and future perspectives regarding the nanotechnology‐integrated BNVs for the diagnosis and treatment of brain diseases are also discussed and outlined.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Extracellular vesicles in disease · MicroRNA in disease regulation · Circular RNAs in diseases
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
CAS Key Laboratory of Standardization and Measurement for Nanotechnology CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China
Departments of Diagnostic Radiology, Surgery Chemical and Biomolecular Engineering and Biomedical Engineering Yong Loo Lin School of Medicine and College of Design and Engineering National University of Singapore Singapore 119074 Singapore
Nanomedicine Translational Research Program Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore
Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore
Institute of Molecular and Cell Biology Agency for Science, Technology, and Research (A*STAR) 61 Biopolis Drive, Proteos Singapore 138673 Singapore
Department of Neurosurgery The First Affiliated Hospital of Chongqing Medical University 1 Friendship Road Chongqing 400016 China
School of Nanoscience and Engineering University of Chinese Academy of Sciences Beijing 100049 P. R. China
Funding
National University of Singapore · National Medical Research Council · Ministry of Education - Singapore · National Research Foundation · Chinese Academy of Sciences · National Key Research and Development Program of China · National Natural Science Foundation of China
References (100+)
Show source-provided references
1. 10.1038/nrm.2017.12510.1038/nrm.2017.125 ↗
2. 10.1038/s41556-018-0250-910.1038/s41556-018-0250-9 ↗
3. 10.1186/s12943-022-01509-910.1186/s12943-022-01509-9 ↗
4. 10.1038/s41565-021-00931-210.1038/s41565-021-00931-2 ↗
5. 10.1038/s41580-022-00460-310.1038/s41580-022-00460-3 ↗
6. 10.1038/nm.439710.1038/nm.4397 ↗
7. 10.1002/adma.20180289610.1002/adma.201802896 ↗
8. 10.1002/smll.20170215310.1002/smll.201702153 ↗
9. 10.1002/advs.20210278910.1002/advs.202102789 ↗
10. 10.1038/s41573-021-00139-y10.1038/s41573-021-00139-y ↗
11. 10.1021/acsnano.9b0439710.1021/acsnano.9b04397 ↗
12. 10.1038/s41591-019-0349-y10.1038/s41591-019-0349-y ↗
13. 10.1021/acs.accounts.0c0033410.1021/acs.accounts.0c00334 ↗
14. 10.1021/jacs.8b1390210.1021/jacs.8b13902 ↗
15. 10.1038/s41392-022-00894-310.1038/s41392-022-00894-3 ↗
16. 10.1080/20013078.2020.173524910.1080/20013078.2020.1735249 ↗
17. 10.1186/s12951-021-01192-w10.1186/s12951-021-01192-w ↗
18. 10.1002/advs.20210322210.1002/advs.202103222 ↗
19. 10.1002/adma.20190404010.1002/adma.201904040 ↗
20. 10.1186/s12951-022-01584-610.1186/s12951-022-01584-6 ↗
21. 10.1186/s13075-019-1867-110.1186/s13075-019-1867-1 ↗
22. 10.1038/s41467-019-11534-w10.1038/s41467-019-11534-w ↗
23. 10.1038/s41467-019-09720-x10.1038/s41467-019-09720-x ↗
24. 10.1111/cas.1528810.1111/cas.15288 ↗
25. 10.1080/20013078.2020.180644410.1080/20013078.2020.1806444 ↗
26. 10.1126/sciadv.aay058910.1126/sciadv.aay0589 ↗
27. 10.1007/s00432-015-2029-810.1007/s00432-015-2029-8 ↗
28. 10.1080/21541248.2016.121528310.1080/21541248.2016.1215283 ↗
29. 10.1186/s12951-022-01358-010.1186/s12951-022-01358-0 ↗
30. 10.1039/C7NR08360B10.1039/C7NR08360B ↗
31. 10.1016/j.jneuroim.2015.09.00610.1016/j.jneuroim.2015.09.006 ↗
32. 10.1089/ten.tea.2019.024010.1089/ten.tea.2019.0240 ↗
33. 10.1126/sciadv.aay978910.1126/sciadv.aay9789 ↗
34. 10.1080/2162402X.2017.128258910.1080/2162402X.2017.1282589 ↗
35. 10.1016/j.jconrel.2019.10.04310.1016/j.jconrel.2019.10.043 ↗
36. 10.1073/pnas.161389111310.1073/pnas.1613891113 ↗
37. 10.1038/nature0355010.1038/nature03550 ↗
38. 10.1038/3507001910.1038/35070019 ↗
39. 10.1016/S0960-9822(01)00587-510.1016/S0960-9822(01)00587-5 ↗
40. 10.1002/advs.20200492910.1002/advs.202004929 ↗
41. 10.1002/jev2.1210910.1002/jev2.12109 ↗
42. 10.1016/j.bioactmat.2021.08.00810.1016/j.bioactmat.2021.08.008 ↗
43. 10.1016/j.biomaterials.2020.11992510.1016/j.biomaterials.2020.119925 ↗
44. 10.1021/acsami.1c0804410.1021/acsami.1c08044 ↗
45. 10.3390/cells812150910.3390/cells8121509 ↗
46. 10.1126/sciadv.aaz095210.1126/sciadv.aaz0952 ↗
47. 10.1016/j.biomaterials.2020.11994210.1016/j.biomaterials.2020.119942 ↗
48. 10.1016/j.jconrel.2021.07.00410.1016/j.jconrel.2021.07.004 ↗
49. 10.1016/j.biomaterials.2017.02.04110.1016/j.biomaterials.2017.02.041 ↗
50. 10.1002/adma.20170675910.1002/adma.201706759 ↗
51. 10.1016/j.apsb.2019.01.01110.1016/j.apsb.2019.01.011 ↗
52. 10.1016/j.nantod.2020.10098610.1016/j.nantod.2020.100986 ↗
53. 10.1126/sciadv.aaz901410.1126/sciadv.aaz9014 ↗
54. 10.1002/adma.20190514510.1002/adma.201905145 ↗
55. 10.1002/adma.20200336810.1002/adma.202003368 ↗
56. 10.1021/acsnano.2c0903310.1021/acsnano.2c09033 ↗
57. 10.1021/acsnano.6b0469510.1021/acsnano.6b04695 ↗
58. 10.1021/nl500618u10.1021/nl500618u ↗
59. 10.3390/pharmaceutics1410200810.3390/pharmaceutics14102008 ↗
60. 10.1021/acscentsci.2c0074110.1021/acscentsci.2c00741 ↗
61. 10.1016/j.jconrel.2020.04.03110.1016/j.jconrel.2020.04.031 ↗
62. 10.1038/s41551-022-00886-210.1038/s41551-022-00886-2 ↗
63. 10.18632/aging.20398910.18632/aging.203989 ↗
64. 10.1016/j.jconrel.2015.03.03310.1016/j.jconrel.2015.03.033 ↗
65. 10.1016/j.biomaterials.2018.06.02910.1016/j.biomaterials.2018.06.029 ↗
66. 10.1016/j.biomaterials.2017.10.01210.1016/j.biomaterials.2017.10.012 ↗
67. 10.1186/s12974-020-01761-010.1186/s12974-020-01761-0 ↗
68. 10.1021/acsnano.2c1284010.1021/acsnano.2c12840 ↗
69. 10.1021/acsnano.2c0975210.1021/acsnano.2c09752 ↗
70. 10.1021/acsnano.1c0868910.1021/acsnano.1c08689 ↗
71. 10.1021/acsnano.0c0797310.1021/acsnano.0c07973 ↗
72. 10.1016/j.actbio.2021.12.02310.1016/j.actbio.2021.12.023 ↗
73. 10.1007/s12035-022-02762-110.1007/s12035-022-02762-1 ↗
74. 10.1016/j.neuroscience.2018.09.01710.1016/j.neuroscience.2018.09.017 ↗
75. 10.1021/acsnano.2c0305510.1021/acsnano.2c03055 ↗
76. 10.2174/156720261466617100515343410.2174/1567202614666171005153434 ↗
77. 10.7150/ijms.3966710.7150/ijms.39667 ↗
78. 10.1038/s41598-019-43607-710.1038/s41598-019-43607-7 ↗
79. 10.3389/fnins.2023.114592310.3389/fnins.2023.1145923 ↗
80. 10.3390/ijms2315839810.3390/ijms23158398 ↗
81. 10.1002/jnr.2469610.1002/jnr.24696 ↗
82. 10.1007/s12035-017-0821-y10.1007/s12035-017-0821-y ↗
83. 10.3390/molecules2301000910.3390/molecules23010009 ↗
84. 10.1021/acs.nanolett.8b0414810.1021/acs.nanolett.8b04148 ↗
85. 10.1126/sciadv.aba396710.1126/sciadv.aba3967 ↗
86. 10.1021/acsnano.7b0449510.1021/acsnano.7b04495 ↗
87. 10.1002/alz.1208910.1002/alz.12089 ↗
88. 10.1158/1078-0432.CCR-22-044410.1158/1078-0432.CCR-22-0444 ↗
89. 10.1038/s41392-020-00258-910.1038/s41392-020-00258-9 ↗
90. 10.1002/adhm.20210134910.1002/adhm.202101349 ↗
91. 10.1002/adma.20180534410.1002/adma.201805344 ↗
92. 10.1186/s12964-020-00623-910.1186/s12964-020-00623-9 ↗
93. 10.7150/thno.3311410.7150/thno.33114 ↗
94. 10.1016/j.jalz.2019.05.00210.1016/j.jalz.2019.05.002 ↗
95. 10.1002/alz.1216610.1002/alz.12166 ↗
96. 10.1186/s12943-018-0897-710.1186/s12943-018-0897-7 ↗
97. 10.1016/j.trecan.2016.05.00810.1016/j.trecan.2016.05.008 ↗
98. 10.1016/j.omtn.2017.04.01010.1016/j.omtn.2017.04.010 ↗
99. 10.1016/j.biomaterials.2021.12087310.1016/j.biomaterials.2021.120873 ↗
100. 10.1016/j.arr.2021.10149710.1016/j.arr.2021.101497 ↗