DataVXAdvanced MaterialsPaper
journal article·2019-10Open access

Development of a Shape‐Memory Tube to Prevent Vascular Stenosis

Yong Cheol Shin, Jung Bok Lee, Dae‐Hyun Kim, Taeyoung Kim, Grant Alexander, Young Min Shin, Ju Young Park, Sewoom Baek, Jeong‐Kee Yoon, Yong Jae Lee, Gyeung Mi Seon, Mi Hee Lee, Mi‐Lan Kang, Woo Soon Jang, Jong‐Chul Park, Ho‐Wook Jun, YongTae Kim, Hak‐Joon Sung

Advanced Materials· Volume 31· Issue 41
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Source abstract

Abstract

Abstract Inserting a graft into vessels with different diameters frequently causes severe damage to the host vessels. Poor flow patency is an unresolved issue in grafts, particularly those with diameters less than 6 mm, because of vessel occlusion caused by disturbed blood flow following fast clotting. Herein, successful patency in the deployment of an ≈2 mm diameter graft into a porcine vessel is reported. A new library of property‐tunable shape‐memory polymers that prevent vessel damage by expanding the graft diameter circumferentially upon implantation is presented. The polymers undergo seven consecutive cycles of strain energy‐preserved shape programming. Moreover, the new graft tube, which features a diffuser shape, minimizes disturbed flow formation and prevents thrombosis because its surface is coated with nitric‐oxide‐releasing peptides. Improved patency in a porcine vessel for 18 d is demonstrated while occlusive vascular remodeling occurs. These insights will help advance vascular graft design.
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Research context

PolymersBiomaterials

OpenAlex topics: Electrospun Nanofibers in Biomedical Applications · Polymer composites and self-healing · Polymer Surface Interaction Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Medical Engineering Yonsei University College of Medicine Seoul 03722 Republic of Korea

George W. Woodruff School of Mechanical Engineering Wallace H. Coulter Department of Biomedical Engineering Institute for Electronics and Nanotechnology Parker H. Petit Institute for Bioengineering and Bioscience Georgia Institute of Technology Atlanta GA 30332 USA

Endomimetics LLC Birmingham AL 35203 USA

Anas Meditech Seoul 08504 Republic of Korea

Department of Obstetrics and Gynecology Yonsei University College of Medicine Seoul 03722 Republic of Korea

Brain Korea 21 PLUS Project for Medical Science Yonsei University College of Medicine Seoul 03722 Republic of Korea

TMD Lab. Seoul 03722 Republic of Korea

Department of Biomedical Engineering University of Alabama at Birmingham Birmingham AL 35294 USA

Funding

National Research Foundation of Korea

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