DataVXAdvanced MaterialsPaper
journal article·2024-10

Targeting the Labile Iron Pool with Engineered DFO Nanosheets to Inhibit Ferroptosis for Parkinson's Disease Therapy

Li Lei, Jiali Yuan, Zhijun Dai, Song Xiang, Qiuxia Tu, Xing Cui, Suzhen Zhai, Xiaozhong Chen, Zhixu He, Boyan Fang, Zhiai Xu, Haijun Yu, Lei Tang, Chunlin Zhang

Advanced Materials· Volume 36· Issue 41
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Source abstract

Abstract

Abstract Ferroptosis in neurons is considered one of the key factors that induces Parkinson's disease (PD), which is caused by excessive iron accumulation in the intracellular labile iron pool (LIP). The iron ions released from the LIP lead to the aberrant generation of reactive oxygen species (ROS) to trigger ferroptosis and exacerbate PD progression. Herein, a pioneering design of multifunctional nanoregulator deferoxamine (DFO)‐integrated nanosheets (BDPR NSs) is presented that target the LIP to restrict ferroptosis and protect against PD. The BDPR NSs are constructed by incorporating a brain‐targeting peptide and DFO into polydopamine‐modified black phosphorus nanosheets. These BDPR NSs can sequester free iron ions, thereby ameliorating LIP overload and regulating iron metabolism. Furthermore, the BDPR NSs can decrease lipid peroxidation generation by mitigating ROS accumulation. More importantly, BDPR NSs can specifically accumulate in the mitochondria to suppress ROS generation and decrease mitochondrial iron accumulation. In vivo experiments demonstrated that the BDPR NSs highly efficiently mitigated dopaminergic neuronloss and its associated behavioral disorders by modulating the LIP and inhibiting ferroptosis. Thus, the BDPR‐based nanovectors holds promise as a potential avenue for advancing PD therapy.
Source: crossref · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Trace Elements in Health · Extracellular vesicles in disease · Adenosine and Purinergic Signaling

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry Engineering Research Center for Molecular Medicine College of Basic Medical Science Guizhou Medical University Guiyang 550025 China

Department of Neurosurgery the Affiliated Hospital of Guizhou Medical University Guiyang 550025 China

Department of Biology Engineering Research Center for Molecular Medicine College of Basic Medical Science Guizhou Medical University Guiyang 550025 China

Guizhou Provincial Engineering Technology Research Center for Chemical Drug R&D College of Pharmacy Guizhou Medical University Guiyang 550025 China

The Jinyang Hospital Affiliated to Guizhou Medical University: The Second People's Hospital of Guiyang Guiyang 550025 China

Key Laboratory of Endemic and Ethnic Diseases Ministry of Education & Key Laboratory of Medical Molecular Biology of Guizhou Province Guizhou Medical University Guiyang 550004 China

Parkinson Medical Center Beijing Rehabilitation Hospital Capital Medical University Beijing 100144 China

School of Chemistry and Molecular Engineering East China Normal University Shanghai 200241 China

Center of Pharmaceutics Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China

Funding

National Natural Science Foundation of China · National College Students Innovation and Entrepreneurship Training Program

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