DataVXAdvanced MaterialsPaper
journal article·2024-04Open access

Transient Mild Photothermia Improves Therapeutic Performance of Oral Nanomedicines with Enhanced Accumulation in the Colitis Mucosa

Ya Ma, Shuangquan Gou, Zhenhua Zhu, Jianfeng Sun, Mohammad‐Ali Shahbazi, Tieyan Si, Cheng Xu, Jinlong Ru, Xiaoxiao Shi, Rui L. Reis, Subhas C. Kundu, Bowen Ke, Guangjun Nie, Bo Xiao

Advanced Materials· Volume 36· Issue 14
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Source abstract

Abstract

Abstract The treatment outcomes of oral medications against ulcerative colitis (UC) have long been restricted by low drug accumulation in the colitis mucosa and subsequent unsatisfactory therapeutic efficacy. Here, high‐performance pluronic F127 (P127)‐modified gold shell (AuS)‐polymeric core nanotherapeutics loading with curcumin (CUR) is constructed. Under near‐infrared irradiation, the resultant P127‐AuS@CURs generate transient mild photothermia (TMP; ≈42 °C, 10 min), which facilitates their penetration through colonic mucus and favors multiple cellular processes, including cell internalization, lysosomal escape, and controlled CUR release. This strategy relieves intracellular oxidative stress, improves wound healing, and reduces immune responses by polarizing the proinflammatory M1‐type macrophages to the anti‐inflammatory M2‐type. Upon oral administration of hydrogel‐encapsulating P127‐AuS@CURs plus intestinal intralumen TMP, their therapeutic effects against acute and chronic UC are demonstrated to be superior to those of a widely used clinical drug, dexamethasone. The treatment of P127‐AuS@CURs (+ TMP) elevates the proportions of beneficial bacteria (e.g., Lactobacillus and Lachnospiraceae), whose metabolites can also mitigate colitis symptoms by regulating genes associated with antioxidation, anti‐inflammation, and wound healing. Overall, the intestinal intralumen TMP offers a promising approach to enhance the therapeutic outcomes of noninvasive medicines against UC.
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Research context

PolymersNanomaterials

OpenAlex topics: Antimicrobial Peptides and Activities · Nanoplatforms for cancer theranostics · Curcumin's Biomedical Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Resource Insects College of Sericulture Textile and Biomass Sciences Southwest University Chongqing 400715 China

Department of Gastroenterology The First Affiliated Hospital of Nanchang University Nanchang 330006 China

Botnar Research Centre Nuffield Department of Orthopedics Rheumatology and Musculoskeletal Sciences University of Oxford Headington Oxford OX3 7LD UK

Department of Biomedical Engineering University Medical Center Groningen University of Groningen Antonius Deusinglaan 1 Groningen 9713 AV Netherlands

School of Physics Harbin Institute of Technology Harbin 150001 China

Chair of Prevention of Microbial Diseases School of Life Sciences Weihenstephan Technical University of Munich 85354 Freising Germany

3Bs Research Group I3Bs — Research Institute on Biomaterials Biodegradables and Biomimetics University of Minho Headquarters of the European Institute of Excellence on Tissue Engineering and Regenerative Medicine AvePark, Barco Guimaraes 4805‐017 Portugal

ICVS/3B's‐PT Government Associate Laboratory Braga Guimaraes 4800‐058 Portugal

Department of Anesthesiology Laboratory of Anesthesia and Critical Care Medicine National‐Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu 610041 China

CAS Key Laboratory for Biomedical Effects of Nanomaterials & Nanosafety CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China

Funding

National Natural Science Foundation of China · Philippine Council for Industry, Energy, and Emerging Technology Research and Development · Support Program for Starting up Innovation Hub · Fundamental Research Funds for Central Universities of the Central South University

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