journal article·2023-09Open access

Langmuir–Blodgett‐Mediated Formation of Antibacterial Microneedles for Long‐Term Transdermal Drug Delivery

Ziyi Lu, Shan Du, Jiaxun Li, Min Zhang, Huali Nie, Xiaojun Zhou, Fulun Li, Xinwei Wei, Jinqiang Wang, Fuyao Liu, Chuanglong He, Guang Yang, Zhen Gu

Advanced Materials· Volume 35· Issue 38

Abstract

Abstract Microneedles (MNs) have become versatile platforms for minimally invasive transdermal drug delivery devices. However, there are concerns about MN‐induced skin infections with long‐term transdermal administration. Using the Langmuir–Blodgett (LB) technique, a simple method for depositing antibacterial nanoparticles of various shapes, sizes, and compositions onto MNs is developed. This strategy has merits over conventional dip coating techniques, including controlled coating layers, uniform and high coverage, and a straightforward fabrication process. This provides MNs with a fast‐acting and long‐lasting antibacterial effect. This study demonstrates that antibacterial MNs achieve superior bacterial elimination in vitro and in vivo without sacrificing payload capacity, drug release, or mechanical strength. It is believed that such a functional nanoparticle coating technique offers a platform for the expansion of MNs function, especially in long‐term transdermal drug delivery fields.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Advancements in Transdermal Drug Delivery · Dermatology and Skin Diseases · Lipid Membrane Structure and Behavior

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Shanghai Engineering Research Center of Nano‐Biomaterials and Regenerative Medicine College of Biological Science and Medical Engineering Donghua University Shanghai 201620 China

College of Basic Medicine Naval Medical University Shanghai 200433 China

College of Chemistry and Chemical Engineering Shanghai University of Engineering Science Shanghai 201620 China

Department of Dermatology Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine Shanghai 200437 China

Key Laboratory for Advanced Drug Delivery Systems of Zhejiang Province College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China

State Key Laboratory of Molecular Engineering of Polymers Fudan University Shanghai 200438 China

Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Jinhua Institute of Zhejiang University Jinhua 321299 China

Liangzhu Laboratory Zhejiang University Medical Center Hangzhou 311121 China

National Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang University Hangzhou 310058 China

Funding

Natural Science Foundation of Shanghai Municipality · Science and Technology Commission of Shanghai Municipality

References (40)

Show source-provided references
1. 10.1016/j.mattod.2021.03.01210.1016/j.mattod.2021.03.012 ↗
2. 10.1038/s41551-018-0337-410.1038/s41551-018-0337-4 ↗
3. 10.1016/j.addr.2021.11391910.1016/j.addr.2021.113919 ↗
4. 10.1038/s41551-019-0508-y10.1038/s41551-019-0508-y ↗
5. 10.1002/adfm.20220584710.1002/adfm.202205847 ↗
6. 10.1021/acsnano.8b0957310.1021/acsnano.8b09573 ↗
7. 10.1002/adfm.20200008610.1002/adfm.202000086 ↗
8. 10.1039/C8CC06035E10.1039/C8CC06035E ↗
9. 10.1016/j.it.2018.02.00410.1016/j.it.2018.02.004 ↗
10. 10.1021/acsami.9b0257810.1021/acsami.9b02578 ↗
11. 10.1016/j.nantod.2022.10163010.1016/j.nantod.2022.101630 ↗
12. 10.1021/acsnano.1c0603610.1021/acsnano.1c06036 ↗
13. 10.1002/adhm.20210005610.1002/adhm.202100056 ↗
14. 10.1021/acsami.2c0250310.1021/acsami.2c02503 ↗
15. 10.1002/adma.20200212910.1002/adma.202002129 ↗
16. 10.1039/D0BM02136A10.1039/D0BM02136A ↗
17. 10.1016/j.bioactmat.2021.04.03310.1016/j.bioactmat.2021.04.033 ↗
18. 10.1002/adfm.20170343710.1002/adfm.201703437 ↗
19. 10.1039/D2CS00460G10.1039/D2CS00460G ↗
20. 10.1002/adfm.20210021810.1002/adfm.202100218 ↗
21. 10.1002/smll.20200043610.1002/smll.202000436 ↗
22. 10.1021/acsami.8b1898110.1021/acsami.8b18981 ↗
23. 10.1016/j.cej.2022.13614010.1016/j.cej.2022.136140 ↗
24. 10.1177/247263031881235010.1177/2472630318812350 ↗
25. 10.1088/1758-5082/1/4/04100110.1088/1758-5082/1/4/041001 ↗
26. 10.1007/s11837-011-0093-310.1007/s11837-011-0093-3 ↗
27. 10.1021/acs.chemrev.1c0075410.1021/acs.chemrev.1c00754 ↗
28. 10.1016/S0008-6223(03)00293-810.1016/S0008-6223(03)00293-8 ↗
29. 10.1002/anie.20200080210.1002/anie.202000802 ↗
30. 10.1039/C1CS15145B10.1039/C1CS15145B ↗
31. 10.1016/j.ccr.2020.21345810.1016/j.ccr.2020.213458 ↗
32. 10.1039/C6TA06018H10.1039/C6TA06018H ↗
33. 10.1002/adma.20180648010.1002/adma.201806480 ↗
34. 10.1021/acsami.2c0596510.1021/acsami.2c05965 ↗
35. 10.1002/adma.20210164910.1002/adma.202101649 ↗
36. 10.1016/j.cej.2019.12223810.1016/j.cej.2019.122238 ↗
37. 10.1021/jacs.8b1220610.1021/jacs.8b12206 ↗
38. 10.1002/adma.20190117910.1002/adma.201901179 ↗
39. 10.1039/C6GC01613H10.1039/C6GC01613H ↗
40. 10.1021/acs.inorgchem.9b0028810.1021/acs.inorgchem.9b00288 ↗