DataVXAdvanced MaterialsPaper
journal article·2021-07

Adipocyte‐Derived Anticancer Lipid Droplets

Tingxizi Liang, Di Wen, Guojun Chen, Amanda Chan, Zhaowei Chen, Hongjun Li, Zejun Wang, Xiao Han, Liping Jiang, Jun‐Jie Zhu, Zhen Gu

Advanced Materials· Volume 33· Issue 26
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Source abstract

Abstract

Abstract Engineering of efficient and safe materials remains a challenge for cancer therapy. Here, the lipid droplet, an organelle in adipocytes, is demonstrated to be a controllable and biocompatible vehicle to deliver anticancer drugs. It is validated that isolated lipid droplets maintain their key physiological functions to interact with other organelles and augment the therapeutic effect of cancer photodynamic therapy by encapsulation with a lipid‐conjugated photosensitizer (Pyrolipid) through a variety of pathways, including generation of reactive oxygen species (ROS); lipid peroxidation; and endoplasmic reticulum (ER) stress. As such, the IC50 value of Pyrolipid is reduced by 6.0‐fold when loaded into the lipid droplet. Of note, in vivo results demonstrate that engineered lipid droplets induce significant inhibition of tumor growth with minimal side effects.
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Research context

Biomaterials

OpenAlex topics: Lipid metabolism and biosynthesis · Endoplasmic Reticulum Stress and Disease · Cancer, Hypoxia, and Metabolism

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Bioengineering University of California, Los Angeles Los Angeles CA 90095 USA

State Key Laboratory of Analytical Chemistry and Collaborative Innovation Center of Chemistry for Life Sciences School of Chemistry & Chemical Engineering Nanjing University Nanjing 210023 China

Jonsson Comprehensive Cancer Center California NanoSystems Institute Los Angeles CA 90095 USA

College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China

Zhejiang Laboratory of Systems & Precision Medicine Zhejiang University Medical Center Hangzhou 311121 China

Department of General Surgery Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou 310016 China

Funding

University of California, Los Angeles · Zhejiang University · National Natural Science Foundation of China · China Scholarship Council

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