Efficient and Targeted Suppression of Human Lung Tumor Xenografts in Mice with Methotrexate Sodium Encapsulated in All‐Function‐in‐One Chimeric Polymersomes

Anisamide-functionalized reversibly crosslinked chimeric polymersomes emerge as an “all-function-in-one” nanoplatform for efficient loading and targeted delivery of methotrexate disodium, a potent water-soluble anticancer drug, to sigma receptor overexpressing H460 nonsmall lung cancer xenografts in vivo, leading to markedly improved tumor-growth inhibition and survival rate and depleted adverse effects as compared to the clinically used formulation (Trexall). As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.