Source abstract
Abstract
Abstract Biomaterial scaffolds have served as the foundation of tissue engineering and regenerative medicine. However, scaffold systems are often difficult to scale in size or shape in order to fit defect‐specific dimensions, and thus provide only limited spatiotemporal control of therapeutic delivery and host tissue responses. Here, a lithography‐based 3D printing strategy is used to fabricate a novel miniaturized modular microcage scaffold system, which can be assembled and scaled manually with ease. Scalability is based on an intuitive concept of stacking modules, like conventional toy interlocking plastic blocks, allowing for literally thousands of potential geometric configurations, and without the need for specialized equipment. Moreover, the modular hollow‐microcage design allows each unit to be loaded with biologic cargo of different compositions, thus enabling controllable and easy patterning of therapeutics within the material in 3D. In summary, the concept of miniaturized microcage designs with such straight‐forward assembly and scalability, as well as controllable loading properties, is a flexible platform that can be extended to a wide range of materials for improved biological performance.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: 3D Printing in Biomedical Research · Additive Manufacturing and 3D Printing Technologies · Innovative Microfluidic and Catalytic Techniques Innovation
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Division of Biomaterials and Biomechanics Department of Restorative Dentistry School of Dentistry Oregon Health and Science University Portland OR 97201 USA
Department of Pediatric Dentistry Faculty of Dentistry Mahidol University Bangkok 10400 Thailand
Center for Regenerative Medicine School of Medicine Oregon Health and Science University Portland OR 97239 USA
Division of Biomaterials and Biomimetics School of Dentistry New York University New York NY 10010 USA
Phil and Penny Knight Campus for Accelerating Scientific Impact University of Oregon Eugene OR 97403 USA
Department of Biomedical Engineering School of Medicine Oregon Health and Science University Portland OR 97239 USA
Cancer Early Detection Advanced Research Center (CEDAR) Knight Cancer Institute Oregon Health and Science University Portland OR 97201 USA
Funding
National Institute of Dental and Craniofacial Research · Oregon Clinical and Translational Research Institute
References (28)
Show source-provided references
2. Thrivikraman G. · 2017 · 349
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