DataVXAdvanced MaterialsPaper
journal article·2022-04

Hetero‐Integration of Silicon Nanomembranes with 2D Materials for Bioresorbable, Wireless Neurochemical System

Seung Min Yang, Jae Hyung Shim, Hyun‐U Cho, Tae‐Min Jang, Gwan‐Jin Ko, Jeongeun Shim, Tae Hee Kim, Jia Zhu, Sangun Park, Yoon Seok Kim, Su‐Yeon Joung, Jong Chan Choe, Jeong‐Woong Shin, Joong Hoon Lee, Yu Min Kang, Huanyu Cheng, Youngmee Jung, Chul‐Ho Lee, Dong Pyo Jang, Suk‐Won Hwang

Advanced Materials· Volume 34· Issue 14
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Source abstract

Abstract

Abstract Although neurotransmitters are key substances closely related to evaluating degenerative brain diseases as well as regulating essential functions in the body, many research efforts have not been focused on direct observation of such biochemical messengers, rather on monitoring relatively associated physical, mechanical, and electrophysiological parameters. Here, a bioresorbable silicon‐based neurochemical analyzer incorporated with 2D transition metal dichalcogenides is introduced as a completely implantable brain‐integrated system that can wirelessly monitor time‐dynamic behaviors of dopamine and relevant parameters in a simultaneous mode. An extensive range of examinations of molybdenum/tungsten disulfide (MoS2/WS2) nanosheets and catalytic iron nanoparticles (Fe NPs) highlights the underlying mechanisms of strong chemical and target‐specific responses to the neurotransmitters, along with theoretical modeling tools. Systematic characterizations demonstrate reversible, stable, and long‐term operational performances of the degradable bioelectronics with excellent sensitivity and selectivity over those of non‐dissolvable counterparts. A complete set of in vivo experiments with comparative analysis using carbon‐fiber electrodes illustrates the capability for potential use as a clinically accessible tool to associated neurodegenerative diseases.
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Research context

NanomaterialsBiomaterialsCatalysis & surfaces

OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Conducting polymers and applications · Advanced Memory and Neural Computing

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

KU‐KIST Graduate School of Converging Science and Technology Korea University 145 Anam‐ro, Seongbuk‐gu Seoul 02841 Republic of Korea

Department of Biomedical Engineering Hanyang University 222, Wangsimni‐ro, Seongdong‐gu Seoul 04763 Republic of Korea

Center for Biomaterials Biomedical Research Institute Korea Institute of Science and Technology (KIST) Seoul 02792 Republic of Korea

Department of Engineering Science and Mechanics The Pennsylvania State University University Park Pennsylvania 16802 USA

Institute of Animal Molecular Biotechnology and Department of Biotechnology College of Life Sciences and Biotechnology Korea University 145, Anam‐ro, Seongbuk‐gu Seoul 02841 Republic of Korea

School of Electrical and Electronic Engineering Yonsei University Seoul 03722 Republic of Korea

Yonsei‐KIST Convergence Research Institute Yonsei University Seoul 03722 Republic of Korea

Department of Integrative Energy Engineering Korea University Seoul 02841 Republic of Korea

Funding

Ministry of Food and Drug Safety · American Chemical Society Petroleum Research Fund · National Science Foundation

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