journal article·2021-11

Skin‐Integrated Devices with Soft, Holey Architectures for Wireless Physiological Monitoring, With Applications in the Neonatal Intensive Care Unit

Sung Soo Kwak, Seonggwang Yoo, Raudel Avila, Ha Uk Chung, Hyoyoung Jeong, Claire Liu, Jamie L. Vogl, Joohee Kim, Hong‐Joon Yoon, Yoonseok Park, Hanjun Ryu, Geumbee Lee, Jihye Kim, Jahyun Koo, Yong Suk Oh, Sungbong Kim, Shuai Xu, Zichen Zhao, Zhaoqian Xie, Yonggang Huang, John A. Rogers

Advanced Materials· Volume 33· Issue 44
Publisher page

Abstract

Abstract Continuous monitoring of vital signs is an essential aspect of operations in neonatal and pediatric intensive care units (NICUs and PICUs), of particular importance to extremely premature and/or critically ill patients. Current approaches require multiple sensors taped to the skin and connected via hard‐wired interfaces to external data acquisition electronics. The adhesives can cause iatrogenic injuries to fragile, underdeveloped skin, and the wires can complicate even the most routine tasks in patient care. Here, materials strategies and design concepts are introduced that significantly improve these platforms through the use of optimized materials, open (i.e., “holey”) layouts and precurved designs. These schemes 1) reduce the stresses at the skin interface, 2) facilitate release of interfacial moisture from transepidermal water loss, 3) allow visual inspection of the skin for rashes or other forms of irritation, 4) enable triggered reduction of adhesion to reduce the probability for injuries that can result from device removal. A combination of systematic benchtop testing and computational modeling identifies the essential mechanisms and key considerations. Demonstrations on adult volunteers and on a neonate in an operating NICUs illustrate a broad range of capabilities in continuous, clinical‐grade monitoring of conventional vital signs, and unconventional indicators of health status.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Advanced Sensor and Energy Harvesting Materials · Tactile and Sensory Interactions · Dielectric materials and actuators

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Querrey Simpson Institute for Bioelectronics Northwestern University Evanston IL 60208 USA

Department of Mechanical Engineering Northwestern University Evanston IL 60208 USA

Sibel Health Niles IL 60714 USA

Department of Biomedical Engineering Northwestern University Evanston IL 60208 USA

Division of Pediatric Autonomic Medicine Department of Pediatrics Ann & Robert H. Lurie Children's Hospital of Chicago Chicago IL 60611 USA

School of Biomedical Engineering Korea University Seoul 02841 Republic of Korea

Interdisciplinary Program in Precision Public Health Korea University Seoul 02841 Republic of Korea

Department of Mechanical Engineering Korea Advanced Institute of Science and Technology Daejeon 34141 Republic of Korea

Department of Materials Science and Engineering University of Illinois at Urbana Champaign Urbana IL 61801 USA

Department of Dermatology Division of Dermatology Department of Pediatrics Feinberg School of Medicine Northwestern University Chicago IL 60611 USA

State Key Laboratory of Structural Analysis for Industrial Equipment Department of Engineering Mechanics Dalian University of Technology Dalian 116024 China

Ningbo Institute of Dalian University of Technology Ningbo 315016 China

Department of Civil and Environmental Engineering Northwestern University Evanston IL 60208 USA

Department of Materials Science and Engineering Northwestern University Evanston IL 60208 USA

Department of Chemistry Northwestern University Evanston IL 60208 USA

Funding

National Science Foundation · National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities

References (46)

Show source-provided references
1. Wheeler D. S. · 2007
2. Xu J. · Natl. Vital Stat. Rep. · 2018 · 67 · 1
3. 10.1136/bmjinnov-2016-00014510.1136/bmjinnov-2016-000145 ↗
4. 10.1016/0378-3782(90)90105-R10.1016/0378-3782(90)90105-R ↗
5. 10.1053/j.nainr.2014.10.00110.1053/j.nainr.2014.10.001 ↗
6. Tottman A. C. · BMJ J. · 2018 · 103 · F277
7. 10.1126/science.120615710.1126/science.1206157 ↗
8. 10.1038/nature1652110.1038/nature16521 ↗
9. 10.1161/CIRCULATIONAHA.114.00902410.1161/CIRCULATIONAHA.114.009024 ↗
10. 10.1038/ncomms1589410.1038/ncomms15894 ↗
11. 10.1126/scitranslmed.aau164310.1126/scitranslmed.aau1643 ↗
12. 10.1126/sciadv.abe165510.1126/sciadv.abe1655 ↗
13. 10.1073/pnas.201978611710.1073/pnas.2019786117 ↗
14. 10.1002/dev.2210010.1002/dev.22100 ↗
15. 10.1126/sciadv.abg309210.1126/sciadv.abg3092 ↗
16. 10.1002/adhm.20210038310.1002/adhm.202100383 ↗
17. 10.1039/C9MH01211G10.1039/C9MH01211G ↗
18. 10.1126/science.aau078010.1126/science.aau0780 ↗
19. 10.1038/s41591-020-0792-910.1038/s41591-020-0792-9 ↗
20. 10.1097/01.pep.0000176574.70254.6010.1097/01.pep.0000176574.70254.60 ↗
21. 10.3389/fpsyg.2017.0219510.3389/fpsyg.2017.02195 ↗
22. 10.1186/s12887-017-0866-010.1186/s12887-017-0866-0 ↗
23. 10.1007/s00396-013-3021-y10.1007/s00396-013-3021-y ↗
24. 10.1073/pnas.181320811610.1073/pnas.1813208116 ↗
25. 10.1039/D0TB00640H10.1039/D0TB00640H ↗
26. 10.1038/nnano.2017.12510.1038/nnano.2017.125 ↗
27. 10.1038/s41598-020-78580-z10.1038/s41598-020-78580-z ↗
28. 10.1038/s41551-019-0480-610.1038/s41551-019-0480-6 ↗
29. 10.1002/adfm.20200343010.1002/adfm.202003430 ↗
30. 10.1002/smll.20210115110.1002/smll.202101151 ↗
31. 10.1197/j.jht.2005.09.01010.1197/j.jht.2005.09.010 ↗
32. 10.1115/1.400596310.1115/1.4005963 ↗
33. 10.1002/adfm.20150108610.1002/adfm.201501086 ↗
34. 10.1126/scitranslmed.aaf259310.1126/scitranslmed.aaf2593 ↗
35. 10.1016/j.jnn.2017.08.00310.1016/j.jnn.2017.08.003 ↗
36. 10.1089/wound.2015.064210.1089/wound.2015.0642 ↗
37. 10.4103/jdmimsu.jdmimsu_56_1810.4103/jdmimsu.jdmimsu_56_18 ↗
38. 10.1186/s12887-019-1712-310.1186/s12887-019-1712-3 ↗
39. 10.1002/adhm.20150011010.1002/adhm.201500110 ↗
40. 10.1039/C8TB02598C10.1039/C8TB02598C ↗
41. 10.1002/(SICI)1097-4628(19961010)62:2<301::AID-APP5>3.0.CO;2-010.1002/(SICI)1097-4628(19961010)62:2<301::AID-APP5>3.0.CO;2-0 ↗
42. 10.1016/S1381-5148(02)00214-610.1016/S1381-5148(02)00214-6 ↗
43. Crank J. · 1975
44. 10.1177/00219983760100010110.1177/002199837601000101 ↗
45. 10.1002/adma.20180125610.1002/adma.201801256 ↗
46. 10.1016/S0140-6736(86)90837-810.1016/S0140-6736(86)90837-8 ↗