journal article·2025-01Open access

NIR‐II AIE Liposomes for Boosting Type‐I Photodynamic and Mild‐Temperature Photothermal Therapy in Breast Cancer Treatment

Shijie Zhen, Zhe Xu, Meng Suo, Teng Zhang, Meng Lyu, Tianwei Li, Tianfu Zhang, Meijing Li, Zujin Zhao, Ben Zhong Tang

Advanced Materials· Volume 37· Issue 3

Abstract

Abstract Phototheranositcs has recently aroused extreme attention due to its exceptional advantages. However, the poor photothernostic efficiency, limited penetration depth, strong oxygen‐dependence, and inevitable damage to normal tissue of conventional photothernostic materials severely hindered their total theranostic efficacy. Herein, a series of near‐infrared second (NIR‐II) photosensitizers (PSs) featuring aggregation‐induced emission (AIE), NIR‐II fluorescence imaging (FLI), type I photodynamic therapy (PDT) and mild‐temperature photothermal therapy (PTT) are constructed through dual‐strategy methods combining donor group engineering and fluorination engineering. Profiting from sufficient molecular rotors and high electronegativity of fluorine, the developed 2‐(2‐((5‐(4‐((4‐(diphenylamino)phenyl)(phenyl)amino)phenyl)thiophen‐2‐yl)methylene)‐5,6‐difluoro‐3‐oxo‐2,3‐dihydro‐1H‐inden‐1‐ylidene)malononitrile (BTS‐2F) and 2‐(2‐((5‐(4‐(bis(4‐(diphenylamino)phenyl)amino)phenyl)thiophen‐2‐yl)methylene)‐5,6‐difluoro‐3‐oxo‐2,3‐dihydro‐1H‐inden‐1‐ylidene)malononitrile (TTS‐2F) are endowed with NIR‐II AIE property, high radical reactive oxygen species (ROS) generation ability and mild‐temperature photothermal conversion. Through thin film hydration method, the prepared BTS‐2F and TTS‐2F loaded liposomes exhibit significant NIR‐II FLI and improved type‐I PDT/mild‐temperature PTT therapy under laser irradiation both in vitro and orthotopic 4T1 mice models.
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Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Photodynamic Therapy Research Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Guangxi Key Laboratory of Electrochemical and Magneto‐chemical Functional Materials College of Chemistry and Bioengineering Guilin University of Technology Guilin 541006 P. R. China

Affiliated Cancer Hospital & Institute of Guangzhou Medical University School of Biomedical Engineering Guangzhou Medical University Guangzhou 510182 P. R. China

Division of Gastrointestinal Surgery Department of General Surgery Shenzhen People's Hospital (The Second Clinical Medical College Jinan University The First Affiliated Hospital Southern University of Science and Technology) Shenzhen Guangdong 518020 P. R. China

State Key Laboratory of Luminescent Materials and Devices Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates South China University of Technology Guangzhou 510640 P. R. China

School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong Shenzhen (CUHK‐Shenzhen) Shenzhen Guangdong 518172 China

Funding

National Natural Science Foundation of China · Science and Technology Support Plan for Youth Innovation of Colleges and Universities of Shandong Province of China · Basic and Applied Basic Research Foundation of Guangdong Province

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