Instant Protection Spray for Anti‐Infection and Accelerated Healing of Empyrosis
Source abstract
Abstract
Abstract Distinct from common injuries, deep burns often require a chronic recovery cycle for healing and long‐term antibiotic treatment to prevent infection. The rise of drug‐resistant bacteria has caused antibiotics to no longer be perfect, and continuous drug use can easily lead to repeated infection and even death. Inspired by wild animals that chew plants to prevent wound infection, probiotic extracts with a structure similar to the tailspike of phage are obtained from Lactobacillus casei and combined with different flavones to design a series of nonantibiotic bactericides. These novel antibacterial agents are combined with a rapid gelation spray with a novel cross‐angle layout to form an instant protection spray (IPS) and provide a physical and anti‐infectious barrier for burns within 30 s. This IPS is able to sterilize 100.00% and 96.14% of multidrug‐resistant Staphylococcus aureus (MRSA) in vitro and in vivo, respectively. In addition, it is found to effectively reduce inflammation in MRSA‐infected burns in rats and to promote tissue healing.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Wound Healing and Treatments · Antimicrobial Peptides and Activities · Antimicrobial agents and applications
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Materials Science & Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China Tianjin University Yaguan Road 135 Tianjin 300072 China
Biomedical Materials Engineering Research Center Hubei Key Laboratory of Polymer Materials Ministry‐of‐Education Key Laboratory for the Green Preparation and Application of Functional Materials School of Materials Science & Engineering Hubei University Wuhan 430062 China
School of Materials Science & Engineering Peking University Yi‐He‐Yuan Road 5 Beijing 100871 China
School of Health Science & Biomedical Engineering Hebei University of Technology Xiping Avenue 5340 Tianjin 300401 China
Funding
National Natural Science Foundation of China · China National Funds for Distinguished Young Scientists · Natural Science Foundation of Beijing Municipality
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