DataVXAdvanced MaterialsPaper
journal article·2025-02

Personalized Vascularized Tumor Organoid‐on‐a‐Chip for Tumor Metastasis and Therapeutic Targeting Assessment

Yang Du, Yi‐Ran Wang, Qi‐Yuan Bao, Xin‐Xin Xu, Congling Xu, Shaoxuan Wang, Qi Liu, Fan Liu, Yu‐Lian Zeng, Ya‐Jun Wang, Wei Liu, Yixin Liu, Sai‐Xi Yu, Yu‐Chen Chen, Chen Wang, Weibin Zhang, Hai Gao, Hao Luo, Baohong Liu, Guangyin Jing, Ming Guo, Fei Xavier Chen, Yan‐Jun Liu

Advanced Materials· Volume 37· Issue 6
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Source abstract

Abstract

Abstract While tumor organoids have revolutionized cancer research by recapitulating the cellular architecture and behaviors of real tumors in vitro, their lack of functional vasculature hinders their attainment of full physiological capabilities. Current efforts to vascularize organoids are struggling to achieve well‐defined vascular networks, mimicking the intricate hierarchy observed in vivo, which restricts the physiological relevance particularly for studying tumor progression and response to therapies targeting the tumor vasculature. An innovative vascularized patient‐derived tumor organoids (PDTOs)‐on‐a‐chip with hierarchical, tumor‐specific microvasculature is presented, providing a versatile platform to explore tumor‐vascular dynamics and antivascular drug efficacy. It is found that highly metastatic tumor cells induced vessel angiogenesis and simultaneously migrated toward blood vessels via the Notch pathway. The evident association between the angiogenic and migratory capacities of PDTOs and their clinical metastatic outcomes underscores the potential of the innovative platform for evaluating tumor metastasis, thus offering valuable insights for clinical decision‐making. Ultimately, the system represents a promising avenue for advancing the understanding of tumor metastasis and developing personalized treatment strategies based on patient‐specific tumor characteristics.
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Research context

OpenAlex topics: 3D Printing in Biomedical Research · Cancer Cells and Metastasis · Cancer, Hypoxia, and Metabolism

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Shanghai Xuhui Central Hospital Zhongshan‐Xuhui Hospital Shanghai Key Laboratory of Medical Epigenetics Institutes of Biomedical Sciences Department of Chemistry Fudan University Shanghai 200032 China

Department of Orthopaedics Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

Shanghai Key Laboratory for Bone and Joint Diseases Shanghai Institute of Traumatology and Orthopedics Shanghai 200025 China

Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation Clinical Research Center for Anesthesiology and Perioperative Medicine Shanghai Fourth People's Hospital School of Life Sciences and Technology Tongji University Shanghai 200092 China

Fudan University Shanghai Cancer Center and Shanghai Key Laboratory of Medical Epigenetics International Co‐laboratory of Medical Epigenetics and Metabolism (Ministry of Science and Technology) Institutes of Biomedical Sciences Fudan University Shanghai 200032 China

Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA

Department of Anesthesiology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China

School of Physics Northwest University Xi'an 710127 China

Funding

National Natural Science Foundation of China

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