DataVXAdvanced MaterialsPaper
journal article·2021-08

T‐Cell‐Derived Nanovesicles for Cancer Immunotherapy

Jihye Hong, Mikyung Kang, Mungyo Jung, Yun Young Lee, Yongbum Cho, Cheesue Kim, Seuk Young Song, Chun Gwon Park, Junsang Doh, Byung‐Soo Kim

Advanced Materials· Volume 33· Issue 33
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Source abstract

Abstract

Abstract Although T‐cell therapy is a remarkable breakthrough in cancer immunotherapy, the therapeutic efficacy is limited for solid tumors. A major cause of the low efficacy is T‐cell exhaustion by immunosuppressive mechanisms of solid tumors, which are mainly mediated by programmed death‐ligand 1 (PD‐L1) and transforming growth factor‐beta (TGF‐β). Herein, T‐cell‐derived nanovesicles (TCNVs) produced by the serial extrusion of cytotoxic T cells through membranes with micro‐/nanosized pores that inhibit T‐cell exhaustion and exhibit antitumoral activity maintained in the immunosuppressive tumor microenvironment (TME) are presented. TCNVs, which have programmed cell death protein 1 and TGF‐β receptor on their surface, block PD‐L1 on cancer cells and scavenge TGF‐β in the immunosuppressive TME, thereby preventing cytotoxic‐T‐cell exhaustion. In addition, TCNVs directly kill cancer cells via granzyme B delivery. TCNVs successfully suppress tumor growth in syngeneic‐solid‐tumor‐bearing mice. Taken together, TCNV offers an effective cancer immunotherapy strategy to overcome the tumor's immunosuppressive mechanisms.
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Research context

Nanomaterials

OpenAlex topics: CAR-T cell therapy research · Immunotherapy and Immune Responses · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Interdisciplinary Program for Bioengineering Seoul National University Seoul 08826 Republic of Korea

School of Chemical and Biological Engineering Seoul National University Seoul 08826 Republic of Korea

Department of Biomedical Engineering Seoul National University College of Medicine Seoul 03080 Republic of Korea

School of Interdisciplinary Bioscience and Bioengineering (I‐Bio) Pohang University of Science and Technology (POSTECH) Pohang 37673 Republic of Korea

Department of Biomedical Engineering SKKU Institute for Convergence Sungkyunkwan University Suwon 16419 Republic of Korea

Department of Materials Science and Engineering Seoul National University Seoul 08826 Republic of Korea

Institute of Chemical Processes Institute of Engineering Research and BioMAX Seoul National University Seoul 08826 Republic of Korea

Funding

National Research Foundation of Korea · Seoul National University

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