Size‐Transformable Nanostructures: From Design to Biomedical Applications
Source abstract
Abstract
Abstract The size of nanostructures (NSs) strongly affects their chemical and physical properties and further impacts their actions in biological systems. Both small and large NSs possess respective advantages for disease theranostics, and this therefore presents a paradox when choosing NSs with suitable sizes. To overcome this challenge, size‐transformable NSs have emerged as a powerful tool, as they can be manipulated to possess the merits of both types of NSs. Herein, various strategies to construct size‐transformable NSs are summarized, and the recent research progress regarding their biomedical applications, particularly within the fields of cancer and bacterial theranostics, is highlighted. This review will inspire researchers to further develop various methods that can be used to construct size‐transformable NSs for use in novel applications within different fields.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Graphene and Nanomaterials Applications · Advanced biosensing and bioanalysis techniques · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
International Joint Research Center for Molecular Science College of Chemistry and Environmental Engineering Shenzhen University Shenzhen 518060 China
College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen 518060 China
Division of Chemistry and Biological Chemistry School of Physical and Mathematical Sciences Nanyang Technological University 21 Nanyang Link Singapore 637371 Singapore
State Key Laboratory of Bioelectronics School of Biological Science and Medical Engineering Southeast University Nanjing 210096 China
Funding
Agency for Science, Technology and Research · National Research Foundation Singapore · National Natural Science Foundation of China · Shenzhen University
References (100+)
Show source-provided references
1. 10.1021/cr030067f10.1021/cr030067f ↗
2. 10.1038/nnano.2007.38710.1038/nnano.2007.387 ↗
3. 10.1002/adfm.20160218510.1002/adfm.201602185 ↗
4. 10.1002/adtp.20180014010.1002/adtp.201800140 ↗
5. Lee Y. W. · Adv. Therap. · 2019 · 2 · 190004110.1002/adtp.201900041 ↗
6. 10.1039/C9NH00577C10.1039/C9NH00577C ↗
7. 10.1146/annurev-bioeng-071811-15012410.1146/annurev-bioeng-071811-150124 ↗
8. 10.1016/j.cclet.2017.07.00110.1016/j.cclet.2017.07.001 ↗
9. 10.1016/j.jconrel.2018.03.01210.1016/j.jconrel.2018.03.012 ↗
10. 10.1021/acscentsci.9b0113910.1021/acscentsci.9b01139 ↗
11. 10.1016/j.cclet.2020.02.03610.1016/j.cclet.2020.02.036 ↗
12. 10.1021/nl052396o10.1021/nl052396o ↗
13. 10.1038/nnano.2008.3010.1038/nnano.2008.30 ↗
14. 10.1021/acsnano.5b0201710.1021/acsnano.5b02017 ↗
15. 10.1021/la104825u10.1021/la104825u ↗
16. 10.1007/s10856-013-4894-510.1007/s10856-013-4894-5 ↗
17. 10.1016/j.jconrel.2014.07.06110.1016/j.jconrel.2014.07.061 ↗
18. 10.1038/nbt134010.1038/nbt1340 ↗
19. 10.1021/mp800051m10.1021/mp800051m ↗
20. 10.1021/nn500857210.1021/nn5008572 ↗
21. 10.1002/adtp.20190007310.1002/adtp.201900073 ↗
22. 10.1039/C9NH00608G10.1039/C9NH00608G ↗
23. 10.1021/nn301282m10.1021/nn301282m ↗
24. 10.1002/smll.20190164710.1002/smll.201901647 ↗
25. 10.1039/C9TB00681H10.1039/C9TB00681H ↗
26. 10.1021/acsnano.6b0507010.1021/acsnano.6b05070 ↗
27. 10.1021/acs.nanolett.9b0283410.1021/acs.nanolett.9b02834 ↗
28. Oh N. · Int. J. Nanomed. · 2014 · 9 · 51
29. 10.1002/adma.20160489410.1002/adma.201604894 ↗
30. 10.1002/adma.20170109510.1002/adma.201701095 ↗
31. 10.1016/j.biomaterials.2010.09.05910.1016/j.biomaterials.2010.09.059 ↗
32. 10.1021/ja200473610.1021/ja2004736 ↗
33. 10.1021/ja211888a10.1021/ja211888a ↗
34. 10.1073/pnas.131533611010.1073/pnas.1315336110 ↗
35. 10.1021/nn400223a10.1021/nn400223a ↗
36. 10.1021/acsami.7b0406610.1021/acsami.7b04066 ↗
37. 10.1002/anie.20161147910.1002/anie.201611479 ↗
38. Lai Y. H. · Int. J. Nanomed. · 2018 · 13 · 301110.2147/IJN.S161314 ↗
39. 10.1021/acsami.8b0484710.1021/acsami.8b04847 ↗
40. 10.1039/C9CP01427F10.1039/C9CP01427F ↗
41. 10.1016/j.jconrel.2020.02.04310.1016/j.jconrel.2020.02.043 ↗
42. 10.1016/S1359-0286(02)00117-110.1016/S1359-0286(02)00117-1 ↗
43. 10.1016/S0169-409X(02)00228-410.1016/S0169-409X(02)00228-4 ↗
44. 10.1002/adma.20180573010.1002/adma.201805730 ↗
45. 10.1002/adbi.20180010810.1002/adbi.201800108 ↗
46. 10.1002/adma.20170117010.1002/adma.201701170 ↗
47. 10.1021/acsnano.8b0281310.1021/acsnano.8b02813 ↗
48. 10.1016/j.biomaterials.2018.03.04610.1016/j.biomaterials.2018.03.046 ↗
49. 10.1021/acsnano.9b0843410.1021/acsnano.9b08434 ↗
50. 10.1166/jbn.2017.243310.1166/jbn.2017.2433 ↗
51. 10.1073/pnas.152208011310.1073/pnas.1522080113 ↗
52. 10.1073/pnas.101838210810.1073/pnas.1018382108 ↗
53. 10.1039/C5RA12436K10.1039/C5RA12436K ↗
54. 10.1016/j.jconrel.2016.11.00610.1016/j.jconrel.2016.11.006 ↗
55. 10.1002/anie.20200110710.1002/anie.202001107 ↗
56. 10.1021/acsami.8b1639510.1021/acsami.8b16395 ↗
57. 10.1021/acsbiomaterials.8b0160810.1021/acsbiomaterials.8b01608 ↗
58. 10.1002/adma.20190151310.1002/adma.201901513 ↗
59. 10.1002/advs.20190143010.1002/advs.201901430 ↗
60. 10.1016/j.msec.2018.05.01310.1016/j.msec.2018.05.013 ↗
61. 10.1021/acsnano.8b0478710.1021/acsnano.8b04787 ↗
62. 10.1002/adfm.20180777210.1002/adfm.201807772 ↗
63. 10.1021/acsnano.0c0011810.1021/acsnano.0c00118 ↗
64. 10.1021/nn202635310.1021/nn2026353 ↗
65. 10.1002/adma.20190674510.1002/adma.201906745 ↗
66. 10.1021/acsnano.6b0232610.1021/acsnano.6b02326 ↗
67. 10.1002/wnan.128210.1002/wnan.1282 ↗
68. 10.1021/acsnano.0c0026910.1021/acsnano.0c00269 ↗
69. 10.1021/acs.chemmater.7b0475110.1021/acs.chemmater.7b04751 ↗
70. 10.1039/C8CS00081F10.1039/C8CS00081F ↗
71. 10.1002/adma.20180272510.1002/adma.201802725 ↗
72. 10.1016/j.biomaterials.2013.01.07610.1016/j.biomaterials.2013.01.076 ↗
73. 10.1002/adfm.20170033910.1002/adfm.201700339 ↗
74. 10.1021/acs.nanolett.5b0434310.1021/acs.nanolett.5b04343 ↗
75. 10.1021/cr500392w10.1021/cr500392w ↗
76. 10.1039/C5CC07195J10.1039/C5CC07195J ↗
77. 10.1021/ja902062j10.1021/ja902062j ↗
78. 10.1016/j.biomaterials.2019.11946010.1016/j.biomaterials.2019.119460 ↗
79. 10.1021/acs.biomac.8b0024110.1021/acs.biomac.8b00241 ↗
80. 10.1039/C6NR00056H10.1039/C6NR00056H ↗
81. 10.1021/ja807416t10.1021/ja807416t ↗
82. 10.1021/acs.biomac.5b0033610.1021/acs.biomac.5b00336 ↗
83. 10.1039/C6TB02361D10.1039/C6TB02361D ↗
84. 10.1016/j.carbpol.2016.09.09210.1016/j.carbpol.2016.09.092 ↗
85. 10.1126/science.106318710.1126/science.1063187 ↗
86. 10.1002/mabi.20080006510.1002/mabi.200800065 ↗
87. 10.1002/adma.20160586910.1002/adma.201605869 ↗
88. 10.1038/s41565-019-0626-410.1038/s41565-019-0626-4 ↗
89. 10.1002/smll.20170332110.1002/smll.201703321 ↗
90. 10.1021/bm060439510.1021/bm0604395 ↗
91. 10.1016/j.mattod.2020.03.00510.1016/j.mattod.2020.03.005 ↗
92. 10.1002/adma.20170346110.1002/adma.201703461 ↗
93. 10.1002/adfm.20180846210.1002/adfm.201808462 ↗
94. 10.1126/sciadv.aaz476710.1126/sciadv.aaz4767 ↗
95. 10.1021/nl070363y10.1021/nl070363y ↗
96. 10.1039/C9NH00643E10.1039/C9NH00643E ↗
97. 10.1002/adma.20120268710.1002/adma.201202687 ↗
98. 10.1016/j.biomaterials.2014.08.00410.1016/j.biomaterials.2014.08.004 ↗
99. 10.1021/cr068445e10.1021/cr068445e ↗
100. 10.1021/acsnano.9b0574910.1021/acsnano.9b05749 ↗