Realizing Highly Efficient Sonodynamic Bactericidal Capability through the Phonon–Electron Coupling Effect Using Two‐Dimensional Catalytic Planar Defects

Abstract Conferring catalytic defects in sonosensitizers is of paramount importance in reinforcing sonodynamic therapy. However, the formation of such 0D defects is governed by the Schottky defect principle. Herein, 2D catalytic planar defects are designed within Ti₃C₂ sheets to address this challenge. These specific planar slip dislocations with abundant Ti³⁺ species (Ti₃C₂‐SD(Ti³⁺)) can yield surface‐bound O due to the effective activation of O₂, thus resulting in a substantial amount of ¹O₂ generation and the 99.72% ± 0.03% bactericidal capability subject to ultrasound (US) stimulation. It is discovered that the 2D catalytic planar defects can intervene in electron transfer through the phonon drag effect—a coupling effect between surface electrons and US‐triggered phonons—that simultaneously contributes to a dramatic decrease in O₂ activation energy from 1.65 to 0.06 eV. This design has achieved a qualitative leap in which the US catalytic site has transformed from 0D to 2D. Moreover, it is revealed that the electron origin, electron transfer, and visible O₂ activation pathway triggered by US can be attributed to the phonon–electron coupling effect. After coating with neutrophil membrane (NM) proteins, the NM‐Ti₃C₂‐SD(Ti³⁺) sheets further demonstrate a 6‐log₁₀ reduction in methicillin‐resistant Staphylococcus aureus burden in the infected bony tissue.