journal article·2022-07Open access

Defective Fe Metal–Organic Frameworks Enhance Metabolic Profiling for High‐Accuracy Diagnosis of Human Cancers

Jing Yang, Xia Yin, Longzhou Zhang, Xiwen Zhang, Yue Lin, Linzhou Zhuang, Wanshan Liu, Ru Zhang, Xuecheng Yan, Li Shi, Wen Di, Lei Feng, Yi Jia, Jinlan Wang, Kun Qian, Xiangdong Yao

Advanced Materials· Volume 34· Issue 26

Abstract

Abstract Cancers heavily threaten human life; therefore, a high‐accuracy diagnosis is vital to protect human beings from the suffering of cancers. While biopsies and imaging methods are widely used as current technologies for cancer diagnosis, a new detection platform by metabolic analysis is expected due to the significant advantages of fast, simple, and cost‐effectiveness with high body tolerance. However, the signal of molecule biomarkers is too weak to acquire high‐accuracy diagnosis. Herein, precisely engineered metal–organic frameworks for laser desorption/ionization mass spectrometry, allowing favorable charge transfer within the molecule–substrate interface and mitigated thermal dissipation by adjusting the phonon scattering with metal nodes, are developed. Consequently, a surprising signal enhancement of ≈10 000‐fold is achieved, resulting in diagnosis of three major cancers (liver/lung/kidney cancer) with area‐under‐the‐curve of 0.908–0.964 and accuracy of 83.2%–90.6%, which promises a universal detection tool for large‐scale clinical diagnosis of human cancers.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Mass Spectrometry Techniques and Applications · Metabolomics and Mass Spectrometry Studies · Machine Learning in Materials Science

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory for Oncogenes and Related Genes Shanghai Key Laboratory of Gynecologic Oncology Department of Obstetrics and Gynecology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 P. R. China

School of Biomedical Engineering Institute of Medical Robotics and Med‐X Research Institute Shanghai Jiao Tong University Shanghai 200030 P. R. China

School of Materials and Energy and Yunnan Key Laboratory for Micro/Nano Materials & Technology Institute of Optoelectronic Information Materials Yunnan University Kunming Yunnan 650091 P. R. China

School of Physics Southeast University Nanjing 211189 P. R. China

Hefei National Laboratory for Physical Sciences at the Microscale University of Science and Technology of China Hefei Anhui 230026 P. R. China

School of Chemical Engineering East China University of Science and Technology Shanghai 200237 P. R. China

School of Environment and Science Queensland Micro‐ and Nanotechnology Centre Griffith University Nathan Campus Brisbane Queensland 4111 Australia

Instrumental Analysis Center Shanghai Jiao Tong University Shanghai 200030 P. R. China

Department of Applied Chemistry and Zhejiang Carbon Neutral Innovation Institute Zhejiang University of Technology Hangzhou 310032 P. R. China

State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun 130012 P. R. China

Funding

National Natural Science Foundation of China · Ministry of Science and Technology

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