journal article·2022-03

A Facile, Protein‐Derived Supramolecular Theranostic Strategy for Multimodal‐Imaging‐Guided Photodynamic and Photothermal Immunotherapy In Vivo

Hong‐Bo Cheng, Hao Dai, Xiaoqiong Tan, Hao Li, Huihui Liang, Chenyan Hu, Mingwei Huang, Jin Yong Lee, Jing Zhao, Liming Zhou, Yuguang Wang, Liqun Zhang, Juyoung Yoon

Advanced Materials· Volume 34· Issue 11
Publisher page

Abstract

Abstract Theranostic systems that permit both diagnosis and treatment in vivo are highly appealing means by which to meet the demands of precision medicine. However, most such systems remain subject to issues related to complex molecular design and synthesis, potential toxicity, and possible photoactivity changes. Herein, a novel supramolecular theranostic strategy involving biomarker protein activation (BPA) and a host–guest strategy is proposed. To exemplify BPA, a facile “one‐for‐all” nanotheranostic agent for both albumin detection and cancer treatment is demonstrated, which utilizes a nanoparticulate heavy‐atom‐free BODIPY dye derivative (B4 NPs). The fluorescence and photoactivity of BODIPY dyes are completely suppressed by aggregation‐induced self‐quenching in the nanoparticulate state. However, a Balb/c nude mouse model is used to confirm that following the disassembly of injected B4 NPs, BODIPY specifically binds albumin in vivo, accompanied by significantly enhanced biocompatibility and photothermal conversion efficiency. More importantly, this supramolecular host–guest BPA strategy enables the resultant nanoplatform to act as a facile and efficient strategy for photodynamic and photothermal immunotherapy.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Polydiacetylene-based materials and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Organic−Inorganic Composites Beijing Laboratory of Biomedical Materials College of Materials Science and Engineering Beijing University of Chemical Technology 15 North Third Ring Road Beijing 100029 P. R. China

Department of Chemistry and Nanoscience Ewha Womans University Seoul 03760 Korea

National Engineering Laboratory for Digital and Material Technology of Stomatology Center of Digital Dentistry Peking University School and Hospital of Stomatology Beijing 100081 China

Peking University School and Hospital of Stomatology Department of Oral and Maxillofacial Surgery Peking University School and Hospital of Stomatology Beijing 100081 China

Department of Chemistry Sungkyunkwan University Suwon 16419 Korea

Henan Provincial Key Laboratory of Surface & Interface Science School of Material and Chemical Engineering Zhengzhou University of Light Industry Zhengzhou 450002 China

Funding

National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities · Ministry of Education · National Research Foundation of Korea

References (30)

Show source-provided references
1. 10.1021/cr500419810.1021/cr5004198 ↗
2. 10.1039/C7CS00594F10.1039/C7CS00594F ↗
3. 10.1039/C7CS00522A10.1039/C7CS00522A ↗
4. 10.1039/C9CS00326F10.1039/C9CS00326F ↗
5. 10.1126/sciadv.abd761410.1126/sciadv.abd7614 ↗
6. 10.1021/jacs.8b1216710.1021/jacs.8b12167 ↗
7. 10.1039/D0CS00234H10.1039/D0CS00234H ↗
8. 10.1039/C7CS00471K10.1039/C7CS00471K ↗
9. 10.1021/acs.chemrev.5b0026310.1021/acs.chemrev.5b00263 ↗
10. 10.1002/wnan.121710.1002/wnan.1217 ↗
11. 10.1002/adma.20200266110.1002/adma.202002661 ↗
12. 10.1016/j.chempr.2018.12.02410.1016/j.chempr.2018.12.024 ↗
13. 10.1016/j.chempr.2017.05.01010.1016/j.chempr.2017.05.010 ↗
14. 10.1002/smll.20190725610.1002/smll.201907256 ↗
15. 10.1021/acs.chemrev.1c0038110.1021/acs.chemrev.1c00381 ↗
16. 10.1039/C9CS00129H10.1039/C9CS00129H ↗
17. 10.1016/j.ccr.2019.04.00410.1016/j.ccr.2019.04.004 ↗
18. 10.1021/acs.accounts.7b0008710.1021/acs.accounts.7b00087 ↗
19. 10.1002/anie.20190775410.1002/anie.201907754 ↗
20. 10.1021/jacs.6b0539010.1021/jacs.6b05390 ↗
21. 10.1038/s41467-019-10056-910.1038/s41467-019-10056-9 ↗
22. 10.1038/s41467-020-20566-610.1038/s41467-020-20566-6 ↗
23. 10.3390/molecules2516368910.3390/molecules25163689 ↗
24. 10.1002/adma.20190785510.1002/adma.201907855 ↗
25. 10.1002/anie.20200526910.1002/anie.202005269 ↗
26. 10.1002/anie.20210674810.1002/anie.202106748 ↗
27. 10.1002/adma.20180121610.1002/adma.201801216 ↗
28. 10.1016/j.ccr.2019.04.00110.1016/j.ccr.2019.04.001 ↗
29. 10.1039/D0CS00671H10.1039/D0CS00671H ↗
30. 10.1021/acs.jpcc.7b0070910.1021/acs.jpcc.7b00709 ↗