journal article·2007-10-19

Strategies for Optimized Radiolabeling of Nanoparticles for in vivo PET Imaging

G. Sun, J. Xu, A. Hagooly, R. Rossin, Z. Li, D. A. Moore, C. J. Hawker, M. J. Welch, K. L. Wooley

Advanced Materials· Volume 19· Issue 20
Publisher page

Abstract

A new strategy to construct shell crosslinked nanoparticles has been developed, containing large numbers of effective DOTAlysines per particle (> 400) for 64Cu radiolabeling. These 64Cu-complexed nanoparticles show impressive specific activities (ca. 400 μCi μg–1), which suggests that they will serve as highly sensitive in vivo PET tracers at low administering doses.
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Research context

OpenAlex topics: Radiopharmaceutical Chemistry and Applications · Medical Imaging Techniques and Applications · Mass Spectrometry Techniques and Applications

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