journal article·2017-03

Biomimetic Engineering Using Cancer Cell Membranes for Designing Compartmentalized Nanoreactors with Organelle‐Like Functions

Vimalkumar Balasubramanian, Alexandra Correia, Hongbo Zhang, Flavia Fontana, Ermei Mäkilä, Jarno Salonen, Jouni Hirvonen, Hélder A. Santos

Advanced Materials· Volume 29· Issue 11
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Abstract

A new biomimetic nanoreactor design is presented based on cancer cell membrane material in combination with porous silicon nanoparticles. This cellular nanoreactor features a biocompartment enclosed by a cell membrane and readily integrated with cells and supplementing the cellular functions under oxidative stress. The study demonstrates the impact of the nanoreactors on improving cellular functions with a potential to serve as artificial organelles. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
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Research context

OpenAlex topics: Advanced biosensing and bioanalysis techniques · Micro and Nano Robotics · Molecular Junctions and Nanostructures

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Division of Pharmaceutical Chemistry and Technology Faculty of Pharmacy University of Helsinki FI 00014 Helsinki Finland

Harvard John A. Paulson School of Engineering and Applied Sciences Harvard University Cambridge MA 02138 USA

Laboratory of Industrial Physics University of Turku FI 20014 Turku Finland

Funding

Suomen Akatemia · European Research Council · Helsingin Yliopisto · Jane ja Aatos Erkon Säätiö

References (52)

Show source-provided references
1. 10.1039/C2CS35312A10.1039/C2CS35312A ↗
2. 10.1126/science.172.3989.120510.1126/science.172.3989.1205 ↗
3. 10.1002/adma.20150238910.1002/adma.201502389 ↗
4. 10.1038/nnano.2016.5410.1038/nnano.2016.54 ↗
5. 10.1016/j.nantod.2009.02.00110.1016/j.nantod.2009.02.001 ↗
6. 10.1021/acs.nanolett.5b0491110.1021/acs.nanolett.5b04911 ↗
7. 10.1039/C4CC08472A10.1039/C4CC08472A ↗
8. 10.1002/anie.20070112510.1002/anie.200701125 ↗
9. 10.1039/C5CC04590H10.1039/C5CC04590H ↗
10. 10.1038/ncomms312710.1038/ncomms3127 ↗
11. 10.1021/nn300545z10.1021/nn300545z ↗
12. 10.1039/C1CS15240H10.1039/C1CS15240H ↗
13. 10.1016/j.febslet.2011.05.00310.1016/j.febslet.2011.05.003 ↗
14. 10.1016/j.progpolymsci.2016.04.00410.1016/j.progpolymsci.2016.04.004 ↗
15. 10.1021/nl401215n10.1021/nl401215n ↗
16. 10.1002/anie.20100265510.1002/anie.201002655 ↗
17. 10.1002/smll.20150210910.1002/smll.201502109 ↗
18. 10.1039/c1cs15246g10.1039/c1cs15246g ↗
19. 10.2217/nnm.13.22310.2217/nnm.13.223 ↗
20. Vardharajula S. · Int. J. Nanomed. · 2012 · 7 · 536
21. 10.1016/j.biomaterials.2014.07.05010.1016/j.biomaterials.2014.07.050 ↗
22. 10.1021/acsami.5b0703310.1021/acsami.5b07033 ↗
23. 10.1002/cphc.20090091410.1002/cphc.200900914 ↗
24. 10.1038/nbt.350610.1038/nbt.3506 ↗
25. 10.1016/j.actbio.2009.12.04310.1016/j.actbio.2009.12.043 ↗
26. Santos H. A. · 2014
27. 10.1039/c2nr30397c10.1039/c2nr30397c ↗
28. 10.1002/aic.1473510.1002/aic.14735 ↗
29. 10.1016/j.molcatb.2004.03.01210.1016/j.molcatb.2004.03.012 ↗
30. 10.1021/nl500618u10.1021/nl500618u ↗
31. 10.1126/science.682887510.1126/science.6828875 ↗
32. 10.1364/AO.18.00058510.1364/AO.18.000585 ↗
33. 10.1006/abio.1997.239110.1006/abio.1997.2391 ↗
34. 10.1073/pnas.111667010910.1073/pnas.1116670109 ↗
35. 10.1039/c2cs35210a10.1039/c2cs35210a ↗
36. 10.1002/smll.20080145510.1002/smll.200801455 ↗
37. 10.1039/c2an36237f10.1039/c2an36237f ↗
38. 10.1038/nnano.2009.1110.1038/nnano.2009.11 ↗
39. 10.1016/j.bbamem.2006.02.01510.1016/j.bbamem.2006.02.015 ↗
40. 10.1002/chem.20100278210.1002/chem.201002782 ↗
41. 10.1021/jp103137e10.1021/jp103137e ↗
42. Gupta N. · Int. J. Nanomed. · 2012 · 7 · 5491
43. 10.1021/nn300545z10.1021/nn300545z ↗
44. 10.1016/j.freeradbiomed.2012.06.03410.1016/j.freeradbiomed.2012.06.034 ↗
45. 10.1016/j.biomaterials.2013.06.05210.1016/j.biomaterials.2013.06.052 ↗
46. 10.1016/j.biomaterials.2016.03.04610.1016/j.biomaterials.2016.03.046 ↗
47. 10.1016/j.addr.2012.05.00810.1016/j.addr.2012.05.008 ↗
48. 10.1038/nrm380110.1038/nrm3801 ↗
49. 10.1155/2012/93648610.1155/2012/936486 ↗
50. 10.1371/journal.pone.009383710.1371/journal.pone.0093837 ↗
51. 10.1080/1071576040002214510.1080/10715760400022145 ↗
52. 10.4161/oxim.3.4.1285810.4161/oxim.3.4.12858 ↗