Dynamic, 3D‐Pattern Formation Within Enzyme‐Responsive Hydrogels

Dynamic, 3D hydrogel patterns emerge over time in response to cell-secreted enzymes (see image). Composite hydrogels fabricated from engineered proteins exhibit customized half-lives ranging across two orders of magnitude due to slight changes in the primary amino acid sequence. The evolution of internal 3D void structures within these polymeric materials is used to release multiple payload molecules with distinct spatial and temporal delivery profiles. Detailed facts of importance to specialist readers are published as ”Supporting Information”. Such documents are peer-reviewed, but not copy-edited or typeset. They are made available as submitted by the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.