Selenopeptide Nanomedicine Activates Natural Killer Cells for Enhanced Tumor Chemoimmunotherapy
Source abstract
Abstract
Abstract Chemoimmunotherapy using nanotechnology has shown great potential for cancer therapy in the clinic. However, uncontrolled transportation and synergistic responses remain challenges. Here, a self‐assembled selenopeptide nanoparticle that strengthens tumor chemoimmunotherapy through the activation of natural killer (NK) cells by the oxidative metabolite of the selenopeptide is developed. With the advantages of the enzyme‐induced size‐reduction and the reactive‐oxygen‐species‐driven deselenization, this selenopeptide is able to deliver therapeutics, e.g., doxorubicin (DOX), to solid tumors and further activate the NK cells in a programmed manner. Importantly, in vitro and in vivo results prove the mutual promotion between the DOX‐induced chemotherapy and the selenopeptide‐induced immunotherapy, which synergistically contribute to the improved antitumor efficacy. It is anticipated that the selenopeptide may provide a type of promising stimuli‐responsive immune modulator for versatile biomedical applications.
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Research context
OpenAlex topics: Graphene and Nanomaterials Applications · Carbon and Quantum Dots Applications · Nanoplatforms for cancer theranostics
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Tianjin Key Laboratory of Hazardous Waste Safety Disposal and Recycling Technology School of Environmental Science and Safety Engineering Tianjin University of Technology 391 Binshui Xidao, Xiqing District Tianjin 300384 China
CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology (NCNST) No. 11 Beiyitiao, Zhongguancun Beijing 100190 China
University of Chinese Academy of Sciences Beijing 100190 China
Technology Innovation Center of Mass Spectrometry for State Market Regulation Center for Advanced Measurement Science National Institute of Metrology 18, Beisanhuandonglu, Chaoyang District Beijing 100029 China
Funding
National Natural Science Foundation of China · Natural Science Foundation of Tianjin City
References (55)
Show source-provided references
1. 10.1038/s41578-019-0108-110.1038/s41578-019-0108-1 ↗
2. 10.1038/s41571-020-0413-z10.1038/s41571-020-0413-z ↗
3. 10.1038/s41591-018-0014-x10.1038/s41591-018-0014-x ↗
4. 10.1021/acsnano.0c0070810.1021/acsnano.0c00708 ↗
5. 10.1038/s41571-020-0426-710.1038/s41571-020-0426-7 ↗
6. 10.1016/j.cell.2018.10.01410.1016/j.cell.2018.10.014 ↗
7. 10.3322/caac.2159610.3322/caac.21596 ↗
8. 10.1021/acs.accounts.0c0051810.1021/acs.accounts.0c00518 ↗
9. 10.1038/s41577-019-0269-610.1038/s41577-019-0269-6 ↗
10. 10.1038/s41573-020-0090-810.1038/s41573-020-0090-8 ↗
11. 10.1021/acsnano.0c0696210.1021/acsnano.0c06962 ↗
12. 10.1002/adma.20190260410.1002/adma.201902604 ↗
13. 10.1038/s41578-020-00269-610.1038/s41578-020-00269-6 ↗
14. 10.1002/adma.20160662810.1002/adma.201606628 ↗
15. 10.1007/s11426-018-9397-510.1007/s11426-018-9397-5 ↗
16. 10.1038/s41565-020-0679-410.1038/s41565-020-0679-4 ↗
17. 10.1021/acschembio.6b0003110.1021/acschembio.6b00031 ↗
18. 10.1016/j.xcrp.2020.10011110.1016/j.xcrp.2020.100111 ↗
19. 10.1038/s41551-020-0599-510.1038/s41551-020-0599-5 ↗
20. 10.1016/j.nantod.2020.10097510.1016/j.nantod.2020.100975 ↗
21. 10.1002/adma.20200438510.1002/adma.202004385 ↗
22. 10.4049/jimmunol.110061010.4049/jimmunol.1100610 ↗
23. 10.1002/anie.20191445310.1002/anie.201914453 ↗
24. 10.1002/adma.20190756810.1002/adma.201907568 ↗
25. 10.31635/ccschem.020.20200012410.31635/ccschem.020.202000124 ↗
26. 10.1016/j.biomaterials.2019.11937710.1016/j.biomaterials.2019.119377 ↗
27. 10.1021/jacs.1c0564810.1021/jacs.1c05648 ↗
28. 10.1021/ja908124g10.1021/ja908124g ↗
29. 10.1021/acsnano.7b0521410.1021/acsnano.7b05214 ↗
30. 10.1021/acs.macromol.8b0159710.1021/acs.macromol.8b01597 ↗
31. 10.1021/jacs.0c0557310.1021/jacs.0c05573 ↗
32. 10.1016/j.biomaterials.2021.12072110.1016/j.biomaterials.2021.120721 ↗
33. 10.1021/acsbiomaterials.1c0025410.1021/acsbiomaterials.1c00254 ↗
34. 10.1002/adma.20180119810.1002/adma.201801198 ↗
35. 10.1021/acsnano.9b0896210.1021/acsnano.9b08962 ↗
36. 10.1002/anie.20191061510.1002/anie.201910615 ↗
37. 10.1126/sciadv.aay004410.1126/sciadv.aay0044 ↗
38. 10.1021/jacs.0c1307110.1021/jacs.0c13071 ↗
39. 10.1038/s41467-019-12848-510.1038/s41467-019-12848-5 ↗
40. 10.31635/ccschem.020.20190011710.31635/ccschem.020.201900117 ↗
41. 10.1126/sciadv.aaz410710.1126/sciadv.aaz4107 ↗
42. 10.1038/s41565-019-0626-410.1038/s41565-019-0626-4 ↗
43. 10.31635/ccschem.020.20200028310.31635/ccschem.020.202000283 ↗
44. 10.31635/ccschem.021.20210096410.31635/ccschem.021.202100964 ↗
45. 10.1016/j.nantod.2020.10103610.1016/j.nantod.2020.101036 ↗
46. 10.1038/s41557-018-0154-010.1038/s41557-018-0154-0 ↗
47. 10.1002/adma.20170014110.1002/adma.201700141 ↗
48. 10.1016/j.jconrel.2019.12.04010.1016/j.jconrel.2019.12.040 ↗
49. 10.1002/anie.20100190010.1002/anie.201001900 ↗
50. 10.1038/ncomms1229910.1038/ncomms12299 ↗
51. 10.1038/nprot.2017.09010.1038/nprot.2017.090 ↗
52. 10.1038/nrm224010.1038/nrm2240 ↗
53. 10.1002/ijc.2816310.1002/ijc.28163 ↗
54. 10.1158/2159-8290.CD-20-065510.1158/2159-8290.CD-20-0655 ↗
55. 10.1007/s13273-019-00059-410.1007/s13273-019-00059-4 ↗