DataVXAdvanced MaterialsPaper
journal article·2021-07Open access

Infrared‐Emitting Multimodal Nanostructures for Controlled In Vivo Magnetic Hyperthermia

Erving Ximendes, Riccardo Marin, Yingli Shen, Diego Ruiz, Diego Gómez‐Cerezo, Paloma Rodríguez‐Sevilla, Jose Lifante, Perla X. Viveros‐Méndez, Francisco Gámez, David García‐Soriano, Gorka Salas, Carmen Zalbidea, Ana Espinosa, Antonio Benayas, Nuria García‐Carrillo, Lorena Cussó, Manuel Desco, Francisco J. Teran, Beatriz H. Juárez, Daniel Jaque

Advanced Materials· Volume 33· Issue 30
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Source abstract

Abstract

Abstract Deliberate and local increase of the temperature within solid tumors represents an effective therapeutic approach. Thermal therapies embrace this concept leveraging the capability of some species to convert the absorbed energy into heat. To that end, magnetic hyperthermia (MHT) uses magnetic nanoparticles (MNPs) that can effectively dissipate the energy absorbed under alternating magnetic fields. However, MNPs fail to provide real‐time thermal feedback with the risk of unwanted overheating and impeding on‐the‐fly adjustment of the therapeutic parameters. Localization of MNPs within a tissue in an accurate, rapid, and cost‐effective way represents another challenge for increasing the efficacy of MHT. In this work, MNPs are combined with state‐of‐the‐art infrared luminescent nanothermometers (LNTh; Ag2S nanoparticles) in a nanocapsule that simultaneously overcomes these limitations. The novel optomagnetic nanocapsule acts as multimodal contrast agents for different imaging techniques (magnetic resonance, photoacoustic and near‐infrared fluorescence imaging, optical and X‐ray computed tomography). Most crucially, these nanocapsules provide accurate (0.2 °C resolution) and real‐time subcutaneous thermal feedback during in vivo MHT, also enabling the attainment of thermal maps of the area of interest. These findings are a milestone on the road toward controlled magnetothermal therapies with minimal side effects.
Source: crossref · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Random lasers and scattering media · Photoacoustic and Ultrasonic Imaging

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Nanomaterials for Bioimaging Group (nanoBIG) Universidad Autónoma de Madrid Madrid 28049 Spain

IRYCIS Ctra. Colmenar km. 9.100 Madrid 28034 Spain

IMDEA Nanociencia Faraday 9 Cantoblanco Madrid 28049 Spain

Universidad Autónoma de Zacatecas Unidad Académica de Ciencia y Tecnología de la Luz y la Materia Carretera Zacatecas‐Guadalajara km. 6 Ejido la escondida Zacatecas Zacatecas 98160 México

Department of Applied Physical Chemistry Universidad Autónoma de Madrid Francisco Tomás y Valiente, 7 Cantoblanco Madrid 28049 Spain

Nanobiotecnología (IMDEA‐Nanociencia) Unidad Asociada al Centro Nacional de Biotecnología (CSIC) Madrid 28049 Spain

Laboratory Animal Service University of Murcia Murcia 30100 Spain

Departamento de Bioingeniería e Ingeniería Aeroespacial Universidad Carlos III de Madrid Madrid 28911 Spain

Instituto de Investigación Sanitaria Gregorio Marañón Madrid 28007 Spain

Unidad de Imagen Avanzada Centro Nacional de Investigaciones Cardiovasculares (CNIC) Madrid 28029 Spain

Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM) Madrid 28029 Spain

Funding

Ministerio de Ciencia, Innovación y Universidades · Comunidad de Madrid · European Commission · Ministerio de Economía y Competitividad

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