DataVXAdvanced MaterialsPaper
journal article·2019-12

Low Dose of X‐Ray‐Excited Long‐Lasting Luminescent Concave Nanocubes in Highly Passive Targeting Deep‐Seated Hepatic Tumors

Zheng‐Zhe Chen, Liu‐Chun Wang, Divinah Manoharan, Chin‐Lai Lee, Lai‐Chin Wu, Wan‐Ting Huang, Eng‐Yen Huang, Chia‐Hao Su, Hwo‐Shuenn Sheu, Chen‐Sheng Yeh

Advanced Materials· Volume 31· Issue 49
Publisher page
Source abstract

Abstract

Abstract Chromium‐doped zinc gallate, ZnGa2O4:Cr3+ (ZGC), is viewed as a long‐lasting luminescence (LLL) phosphor that can avoid tissue autofluorescence interference for in vivo imaging detection. ZGC is a cubic spinel structure, a typical agglomerative or clustered morphology lacking a defined cubic shape, but a sphere‐like feature is commonly obtained for the nanometric ZGC. The substantial challenge remains achieving a well‐defined cubic feature in nanoscale. The process by which dispersed and well‐defined concave cubic ZGC is obtained is described, exhibiting much stronger LLL in UV and X‐ray excitation for the dispersed cubic ZGC compared with the agglomerative form that cannot be excited using X‐rays with a low dose of 0.5 Gy. The cubic ZGC reveals a specific accumulation in liver and 0.5 Gy used at the end of X‐ray excitation is sufficient for imaging of deep‐seated hepatic tumors. The ZGC nanocubes show highly passive targeting of orthotopic hepatic tumors.
Source: crossref · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence Properties of Advanced Materials · Quantum Dots Synthesis And Properties

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemistry National Cheng Kung University Tainan 701 Taiwan

Institute for Translational Research in Biomedicine Kaohsiung Chang Gung Memorial Hospital Kaohsiung 83301 Taiwan

National Synchrotron Radiation Research Center Hsinchu 30076 Taiwan

Department of Radiation Oncology Chang Gung Memorial Hospital Kaohsiung 83301 Taiwan

Department of Biomedical Imaging and Radiological Sciences National Yang Ming University Taipei 112 Taiwan

Center of Applied Nanomedicine National Cheng Kung University Tainan 701 Taiwan

Department of Medicinal and Applied Chemistry Kaohsiung Medical University Kaohsiung 807 Taiwan

Funding

Ministry of Science and Technology, Taiwan · Chang Gung Medical Foundation · National Cheng Kung University · Ministry of Education

References (24)

Show source-provided references
1. 10.1002/anie.20120605910.1002/anie.201206059 ↗
2. 10.1038/nnano.2009.29410.1038/nnano.2009.294 ↗
3. 10.1073/pnas.070242710410.1073/pnas.0702427104 ↗
4. 10.1038/nmat390810.1038/nmat3908 ↗
5. 10.1021/jacs.5b0087210.1021/jacs.5b00872 ↗
6. 10.1021/acsnano.7b0264310.1021/acsnano.7b02643 ↗
7. 10.1126/science.110427410.1126/science.1104274 ↗
8. 10.1038/nmat139010.1038/nmat1390 ↗
9. 10.1002/anie.20180122610.1002/anie.201801226 ↗
10. 10.1021/acs.analchem.9b0031710.1021/acs.analchem.9b00317 ↗
11. 10.1063/1.489010510.1063/1.4890105 ↗
12. 10.1039/C7MH00442G10.1039/C7MH00442G ↗
13. 10.1002/adfm.20170749610.1002/adfm.201707496 ↗
14. 10.1364/OE.19.01013110.1364/OE.19.010131 ↗
15. 10.1038/nmat317310.1038/nmat3173 ↗
16. 10.1021/cm403050q10.1021/cm403050q ↗
17. 10.1021/ja204504w10.1021/ja204504w ↗
18. 10.1016/j.jlumin.2010.04.00210.1016/j.jlumin.2010.04.002 ↗
19. 10.1002/stem.553001040210.1002/stem.5530010402 ↗
20. 10.1667/RR1892.110.1667/RR1892.1 ↗
21. 10.1016/j.ijbiomac.2018.04.09810.1016/j.ijbiomac.2018.04.098 ↗
22. 10.1002/adfm.20080088010.1002/adfm.200800880 ↗
23. 10.1021/cr020351r10.1021/cr020351r ↗
24. 10.1021/nl902421510.1021/nl9024215 ↗