DataVXAdvanced MaterialsPaper
journal article·2019-11Open access

Nanotherapy in Joints: Increasing Endogenous Hyaluronan Production by Delivering Hyaluronan Synthase 2

Huimin Li, Huilin Guo, Chang Lei, Li Liu, Liqin Xu, Yaping Feng, Jin Ke, Wei Fang, Hao Song, Chun Xu, Chengzhong Yu, Xing Long

Advanced Materials· Volume 31· Issue 46
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Source abstract

Abstract

Abstract Osteoarthritis (OA) is a common joint degenerative disease that causes pain, joint damage, and dysfunction. External hyaluronic acid (HA) supplement is a common method for the management of osteoarthritis which requires multi‐injections. It is demonstrated that biodegradable mesoporous silica nanoparticles successfully deliver an enzyme, hyaluronan synthase type 2 (HAS2), into synoviocytes from the temporomandibular joint (TMJ) and generate endogenous HA with high molecular weights. In a rat TMJ osteoarthritis inflammation model, this strategy promotes endogenous HA production and inhibits the synovial inflammation of OA for more than 3 weeks with one‐shot administration. Such nanotherapy also helps repairing the bone defects in a rat OA bone defect model.
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Research context

Nanomaterials

OpenAlex topics: Proteoglycans and glycosaminoglycans research · Osteoarthritis Treatment and Mechanisms · Tendon Structure and Treatment

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‐MOST) and Key Laboratory of Oral Biomedicine Ministry of Education School and Hospital of Stomatology Wuhan University Wuhan 430079 China

Department of Oral and Maxillofacial Surgery School and Hospital of Stomatology Wuhan University Wuhan 430079 China

Australian Institute for Bioengineering and Nanotechnology The University of Queensland Brisbane QLD 4072 Australia

School of Dentistry The University of Queensland Brisbane Queensland 4066 Australia

Funding

National Natural Science Foundation of China

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