DataVXAdvanced MaterialsPaper
journal article·2015-07Open access

Discovery of a Novel Polymer for Human Pluripotent Stem Cell Expansion and Multilineage Differentiation

Adam D. Celiz, James G. W. Smith, Asha K. Patel, Andrew L. Hook, Divya Rajamohan, Vinoj T. George, Luke Flatt, Minal J. Patel, Vidana C. Epa, Taranjit Singh, Robert Langer, Daniel G. Anderson, Nicholas D. Allen, David C. Hay, David A. Winkler, David A. Barrett, Martyn C. Davies, Lorraine E. Young, Chris Denning, Morgan R. Alexander

Advanced Materials· Volume 27· Issue 27
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Source abstract

Abstract

A scalable and cost-effective synthetic polymer substrate that supports robust expansion and subsequent multilineage differentiation of human pluripotent stem cells (hPSCs) with defined commercial media is presented. This substrate can be applied to common cultureware and used off-the-shelf after long-term storage. Expansion and differentiation of hPSCs are performed entirely on the polymeric surface, enabling the clinical potential of hPSC-derived cells to be realized.
Source: openalex_inverted_index · Quality: baseline

Research context

Polymers

OpenAlex topics: Pluripotent Stem Cells Research · 3D Printing in Biomedical Research · Biomedical Ethics and Regulation

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Laboratory of Biophysics and Surface Analysis School of Pharmacy University of Nottingham Nottingham NG7 2RD UK

Wyss Institute for Biologically Inspired Engineering at Harvard University Boston MA 02115 USA

Wolfson Centre for Stem Cells Tissue Engineering and Modelling School of Medicine Centre for Biomolecular Sciences University of Nottingham Nottingham NG7 2RD UK

David H. Koch Institute for Integrative Cancer Research Department of Chemical Engineering Institute for Medical Engineering and Science Massachusetts Institute of Technology Cambridge MA 02139 USA

CSIRO Manufacturing Flagship 343 Royal Parade Parkville 3052 Australia

Cardiff School of Biosciences The Sir Martin Evans Building Museum Avenue Cardiff CF10 3AX UK

MRC Centre for Regenerative Medicine SCRM Building The University of Edinburgh Edinburgh BioQuarter, 5 Little France Drive Edinburgh EH16 4UU UK

CSIRO Manufacturing Flagship Bayview Avenue Clayton 3168 Australia

Monash Institute of Pharmaceutical Sciences 399 Royal Parade Parkville 3052 Australia

Latrobe Institute for Molecular Science Latrobe University Bundoora 3086 Australia

Centre for Analytical Bioscience School of Pharmacy University of Nottingham Nottingham NG7 2RD UK

Funding

EPSRC

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